Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 3/20 | 0.49 |
| ▸ | CCR9 | P51686 | 2/20 | 0.49 |
| ▸ | S100A9 | P06702 | 2/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.45 |
| ▸ | MTOR | P42345 | 8/20 | 0.44 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | CCR4 | P51679 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28549695 | 0.99 | PIK3CG (0.50) | PIK3CGCCR9S100A9PIK3CAPIK3CD | |
| SCHEMBL358926 | 0.87 | PIK3CG (0.63) | PIK3CGS100A9PIK3CAPIK3CDPIK3CB | |
| SCHEMBL789565 | 0.86 | PIK3CA (0.57) | PIK3CGPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL16551868 | 0.86 | PIK3CA (0.55) | PIK3CGCCR9PIK3CAMTORMEN1 | |
| SCHEMBL15556197 | 0.85 | MTOR (0.55) | PIK3CGPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL22447546 | 0.85 | CCR4 (0.59) | PIK3CGS100A9PIK3CAPIK3CDMTOR | |
| SCHEMBL15648432 | 0.85 | PIK3CG (0.49) | PIK3CGCCR9S100A9PIK3CAPIK3CD | |
| SCHEMBL17022151 | 0.84 | PIK3CA (0.58) | PIK3CGS100A9PIK3CAMTORPIK3R1 | |
| SCHEMBL22447636 | 0.82 | PIK3CG (0.46) | PIK3CGS100A9PIK3CAPIK3CDPIK3CB | |
| SCHEMBL790722 | 0.81 | PIK3CA (0.58) | PIK3CGS100A9PIK3CAMTORMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113214247-A | Azaindole derivative marrow cell proliferation inhibitor, preparation method and application thereof in pharmacy | 复旦大学 | 2021-08-06 | — | — | CN | disclosed |
| CN-112724134-A | Azaindazole bipyridine derivative myeloid cell proliferation inhibitor, preparation method and application thereof in pharmacy | 复旦大学 | 2021-04-30 | — | — | CN | disclosed |