Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.58 |
| ▸ | MTOR | P42345 | 4/20 | 0.58 |
| ▸ | ACLY | P53396 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.51 |
| ▸ | PI4KA | P42356 | 1/20 | 0.51 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
| ▸ | BRD1 | O95696 | 3/20 | 0.47 |
| ▸ | BRPF1 | P55201 | 3/20 | 0.47 |
| ▸ | BRPF3 | Q9ULD4 | 3/20 | 0.47 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.47 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.45 |
| ▸ | CCR2 | P41597 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | S100A9 | P06702 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16551868 | 0.85 | PIK3CA (0.55) | PIK3CAMTORPIK3CGGLO1MEN1 | |
| SCHEMBL22447546 | 0.84 | CCR4 (0.59) | PIK3CAMTORPIK3CGCCR2S100A9 | |
| SCHEMBL15648432 | 0.84 | PIK3CG (0.49) | PIK3CAMTORPIK3CGBRD4S100A9 | |
| SCHEMBL15556197 | 0.84 | MTOR (0.55) | PIK3CAMTORPIK3CG | |
| SCHEMBL358926 | 0.84 | PIK3CG (0.63) | PIK3CAMTORPIK3CGPI4KAS100A9 | |
| SCHEMBL28549695 | 0.83 | PIK3CG (0.50) | PIK3CAMTORPIK3CGMEN1KMT2A | |
| Ammonia Solution, Strong SCHEMBL28564473 | 0.81 | PIK3CG (0.49) | PIK3CAMTORPIK3CGMEN1KMT2A | |
| SCHEMBL17022151 | 0.81 | PIK3CA (0.58) | PIK3CAMTORPIK3CGSLC22A12MEN1 | |
| SCHEMBL789641 | 0.81 | MEN1 (0.52) | PIK3CAPIK3CGMEN1KMT2AS100A9 | |
| SCHEMBL789512 | 0.81 | KEAP1 (0.55) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015120737-A1 | SUBSTITUTED PYRIDOPYRIMIDINE COMPOUNDS, PREPARATION METHODS THEREFOR AND USES THEREOF | 北大方正集团有限公司 | 2015-08-20 | — | — | WO | disclosed |
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |