Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 5/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PKMYT1 | Q99640 | 3/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.32 |
| ▸ | PIM1 | P11309 | 2/20 | 0.32 |
| ▸ | WEE1 | P30291 | 2/20 | 0.32 |
| ▸ | MYT1 | Q01538 | 2/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28550860 | 0.76 | MAPK1 (0.34) | LMNAPOLBHCRTR1HCRTR2 | |
| SCHEMBL11942291 | 0.73 | LMNA (0.47) | LMNANQO2DPP4DPP8GRM2 | |
| SCHEMBL16751985 | 0.70 | LMNA (0.44) | LMNADPP4DPP8GRM2POLB | |
| SCHEMBL16648903 | 0.66 | SIRT3 (0.42) | PKMYT1HCRTR1HCRTR2 | |
| SCHEMBL30625387 | 0.65 | NOS3 (0.48) | LMNAL3MBTL1POLB | |
| SCHEMBL12487400 | 0.65 | LMNA (0.45) | LMNADPP4DPP8GRM2POLB | |
| SCHEMBL22362576 | 0.65 | SIRT3 (0.34) | LMNAPKMYT1HCRTR1HCRTR2 | |
| SCHEMBL7718641 | 0.64 | LMNA (0.54) | LMNANQO2GRM2POLBPIM1 | |
| SCHEMBL3999989 | 0.64 | NOS3 (0.46) | LMNADPP4DPP8L3MBTL1GRM2 | |
| SCHEMBL9426333 | 0.64 | LMNA (0.48) | LMNANQO2L3MBTL1GRM2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108779098-B | Therapeutic compounds | 希四克斯探索有限公司 | 2021-04-09 | — | — | CN | disclosed |