SCHEMBL28567360

SCHEMBL28567360

CC(C)(C)c1ccc2c(c1)c1cc(C(C)(C)C)ccc1n2-c1cc(-c2ccccc2)cc(C#N)c1-c1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.36
KDM4E B2RXH2 2/20 0.36
GLA P06280 1/20 0.36
GAA P10253 1/20 0.36
SERPINE1 P05121 2/20 0.35
KIF11 P52732 2/20 0.34
MAOA P21397 3/20 0.34
MCL1 Q07820 2/20 0.33
NPSR1 Q6W5P4 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
HPGD P15428 1/20 0.33
GABRA1 P14867 1/20 0.32
GABRG2 P18507 1/20 0.32
GABRB3 P28472 1/20 0.32
GABRA5 P31644 1/20 0.32
GABRA3 P34903 1/20 0.32
DNMT1 P26358 3/20 0.32
PGR P06401 1/20 0.32
RORA P35398 1/20 0.32
RORC P51449 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28571070 0.86 MCL1 (0.38) ALDH1A1KDM4EGLAGAAMAOA
SCHEMBL28562707 0.85 KIF11 (0.39) ALDH1A1KDM4EGLAGAASERPINE1
SCHEMBL21840875 0.85 KIF11 (0.37) ALDH1A1KDM4ESERPINE1KIF11NPSR1
SCHEMBL22104619 0.81 ABCG2 (0.35) ALDH1A1KDM4ENPSR1HPGDGABRA1
SCHEMBL23348409 0.81 KIF11 (0.34) ALDH1A1KDM4EGAASERPINE1KIF11
SCHEMBL28581529 0.81 ALDH1A1 (0.39) ALDH1A1KDM4EGAAKIF11NPSR1
SCHEMBL28568120 0.81 ALDH1A1 (0.36) ALDH1A1KDM4EGLAGAASERPINE1
SCHEMBL10029985 0.80 SERPINE1 (0.38) ALDH1A1SERPINE1KIF11NPSR1DNMT1
SCHEMBL22736976 0.80 GABRA1 (0.39) ALDH1A1KDM4EGLAGAASERPINE1
SCHEMBL23348411 0.80 KIF11 (0.36) SERPINE1KIF11DNMT1PGRRORA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112638874-A Benzonitrile derivative, light-emitting material, and light-emitting element using the same 国立大学法人九州大学 2021-04-09 CN disclosed