Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 3/20 | 0.35 |
| ▸ | PYGL | P06737 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13570548 | 0.75 | TOP2A (0.54) | TOP2AMAPK14HCAR3KDM4EALDH1A1 | |
| SCHEMBL2104747 | 0.75 | TOP2A (0.54) | TOP2AMAPK14HCAR3KDM4EALDH1A1 | |
| SCHEMBL2105803 | 0.72 | TOP2A (0.45) | TOP2AMAPK14HCAR3PARP10L3MBTL1 | |
| SCHEMBL6259587 | 0.71 | F10 (0.52) | TOP2AALDH1A1POLBF10KMT2A | |
| SCHEMBL13736515 | 0.70 | KDM4E (0.58) | TOP2AMAPK14KDM4EALDH1A1HSD17B10 | |
| SCHEMBL10818797 | 0.69 | HSD17B10 (0.45) | KDM4EALDH1A1HSD17B10POLBPARP10 | |
| SCHEMBL13450319 | 0.68 | HCAR3 (0.43) | TOP2AMAPK14HCAR3KDM4EALDH1A1 | |
| SCHEMBL2431092 | 0.68 | HCAR3 (0.52) | TOP2AHCAR3KDM4EALDH1A1HSD17B10 | |
| SCHEMBL19788699 | 0.67 | ALOX5 (0.49) | TOP2AHCAR3KDM4EALDH1A1HSD17B10 | |
| SCHEMBL13841105 | 0.67 | HSD17B10 (0.51) | KDM4EALDH1A1HSD17B10POLBPARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112770745-A | Compounds for the treatment of specific leukemias | 拓臻股份有限公司 | 2021-05-07 | — | — | CN | disclosed |