SCHEMBL28570822

SCHEMBL28570822

O=C(Cc1ccc2ccccc2c1)NCCc1ccccc1

nearest known ligand 0.64

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.64
CA2 P00918 2/20 0.64
HSD17B2 P37059 1/20 0.64
CA5A P35218 1/20 0.58
CA7 P43166 1/20 0.58
CA5B Q9Y2D0 1/20 0.58
HPGD P15428 2/20 0.58
GAA P10253 1/20 0.58
MEN1 O00255 2/20 0.57
KMT2A Q03164 2/20 0.57
ALDH1A1 P00352 1/20 0.57
SMN1; SMN2 Q16637 1/20 0.57
NR1H4 Q96RI1 1/20 0.56
EPHX2 P34913 5/20 0.56
LTA4H P09960 4/20 0.56
TRPV1 Q8NER1 2/20 0.55
MTNR1A P48039 1/20 0.54
MTNR1B P49286 1/20 0.54
SIRT5 Q9NXA8 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9002952 0.94 HPGD (0.65) CA1CA2HSD17B2CA5ACA7
SCHEMBL31713941 0.86 NR1H4 (0.57) CA1CA2HSD17B2HPGDGAA
SCHEMBL17946633 0.85 NR1H4 (0.59) GAAMEN1KMT2ASMN1; SMN2NR1H4
SCHEMBL22495484 0.84 ALDH1A1 (0.64) CA1CA2HSD17B2CA5ACA7
SCHEMBL6890675 0.84 MEN1 (0.55) MEN1KMT2AALDH1A1NR1H4
SCHEMBL4153733 0.84 HPGD (0.79) CA1CA2HSD17B2CA5ACA7
SCHEMBL31713830 0.83 MC4R (0.55) MEN1KMT2ANR1H4
SCHEMBL23094939 0.82 L3MBTL1 (0.60) MEN1KMT2ANR1H4
SCHEMBL30940788 0.82 MEN1 (0.52) HPGDGAAMEN1KMT2ANR1H4
SCHEMBL9492795 0.82 MTNR1A (0.67) CA1CA2HPGDMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112851536-B Method for constructing amide bond by clicking pyrimidine condensing agent and application of method in amide and polypeptide synthesis 兰州大学 2022-02-25 CN disclosed
CN-112851536-A Method for constructing amide bond by clicking pyrimidine condensing agent and application of method in amide and polypeptide synthesis 兰州大学 2021-05-28 CN disclosed