SCHEMBL28570870

SCHEMBL28570870

CC(C#N)CCOc1ccccc1-c1nccc(C(=O)O)n1

nearest known ligand 0.54

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
XDH P47989 11/20 0.54
FABP3 P05413 2/20 0.39
PTGER1 P34995 1/20 0.39
KDM4E B2RXH2 2/20 0.37
PKM P14618 1/20 0.37
IDO1 P14902 1/20 0.37
ALDH1A1 P00352 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28579825 0.87 XDH (0.50) XDHFABP3PTGER1KDM4EPKM
SCHEMBL28574651 0.84 XDH (0.47) XDHPTGER1
SCHEMBL28589920 0.82 XDH (0.51) XDHPTGER1KDM4EPKMIDO1
SCHEMBL28587014 0.81 XDH (0.47) XDHPTGER1KDM4EPKMIDO1
SCHEMBL28570869 0.80 XDH (0.48) XDHPTGER1KDM4EPKMALDH1A1
SCHEMBL28575823 0.80 XDH (0.45) XDHPTGER1IDO1
SCHEMBL28570867 0.80 XDH (0.59) XDHKDM4EALDH1A1
SCHEMBL28579824 0.79 XDH (0.46) XDHPTGER1KDM4EPKMALDH1A1
SCHEMBL28914642 0.76 XDH (0.45) XDHPTGER1ALDH1A1
SCHEMBL28583440 0.72 XDH (0.59) XDHPTGER1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112979559-A 2-phenyl pyrimidine formic acid derivative and preparation method and application thereof 沈阳药科大学 2021-06-18 CN claimed
CN-112979559-A 2-phenyl pyrimidine formic acid derivative and preparation method and application thereof 沈阳药科大学 2021-06-18 CN disclosed