Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | CCR1 | P32246 | 5/20 | 0.46 |
| ▸ | TRPC1 | P48995 | 2/20 | 0.41 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.41 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.41 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.41 |
| ▸ | STIM2 | Q9P246 | 2/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GPR6 | P46095 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2859852 | 0.89 | CCR1 (0.49) | MAPTCCR1TRPC3KEAP1NFE2L2 | |
| SCHEMBL2854294 | 0.85 | CCR1 (0.48) | MAPTCCR1TRPC3KEAP1NFE2L2 | |
| SCHEMBL2860192 | 0.85 | CCR1 (0.50) | MAPTCCR1KEAP1NFE2L2KMT2A | |
| SCHEMBL2850444 | 0.85 | CCR1 (0.46) | MAPTCCR1KEAP1NFE2L2KMT2A | |
| SCHEMBL2860237 | 0.79 | MAPT (0.56) | MAPTCCR1TRPC1TRPC3STIM1 | |
| SCHEMBL13513684 | 0.73 | CCR1 (0.54) | MAPTCCR1KEAP1NFE2L2KMT2A | |
| SCHEMBL2325526 | 0.73 | MAPT (0.76) | MAPTTRPC1TRPC3STIM1ORAI1 | |
| SCHEMBL2860236 | 0.71 | MAPT (0.62) | MAPTCCR1TRPC1TRPC3STIM1 | |
| SCHEMBL10366449 | 0.71 | MAPT (0.53) | MAPTCCR1TRPC1TRPC3STIM1 | |
| SCHEMBL2854414 | 0.69 | MAPT (0.53) | MAPTCCR1TRPC1TRPC3STIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |