Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.73 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | DHFR | P00374 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | GUSB | P08236 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5341216 | 0.85 | KIF11 (1.00) | KIF11POLBSMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL17323002 | 0.84 | KIF11 (0.77) | KIF11POLBDHFRSMN1; SMN2NPSR1 | |
| Monastrol SCHEMBL3168349 | 0.84 | KIF11 (0.77) | KIF11POLBDHFRALDH1A1GUSB | |
| S-Menastrol SCHEMBL74457 | 0.84 | KIF11 (0.77) | KIF11POLBDHFRALDH1A1GUSB | |
| SCHEMBL11785984 | 0.78 | KDM4E (0.70) | KIF11POLBSMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL29155697 | 0.77 | KIF11 (0.66) | KIF11POLBDHFRSMN1; SMN2NPSR1 | |
| SCHEMBL3397866 | 0.74 | PKM (0.80) | KIF11SMN1; SMN2ALDH1A1PKMKDM4E | |
| SCHEMBL3341613 | 0.74 | KIF11 (0.62) | KIF11POLBDHFRSMN1; SMN2ALDH1A1 | |
| SCHEMBL3435307 | 0.74 | KIF11 (0.76) | KIF11POLBSMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL3399033 | 0.74 | KIF11 (0.79) | KIF11SMN1; SMN2NPSR1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107667092-B | Formylated N-heterocyclic derivatives as FGFR4 inhibitors | 诺华股份有限公司 | 2021-05-28 | — | — | CN | disclosed |