Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 3/20 | 0.31 |
| ▸ | CTSS | P25774 | 3/20 | 0.31 |
| ▸ | CTSK | P43235 | 3/20 | 0.31 |
| ▸ | CTSH | P09668 | 1/20 | 0.31 |
| ▸ | FNTA | P49354 | 10/20 | 0.31 |
| ▸ | FNTB | P49356 | 10/20 | 0.31 |
| ▸ | PGGT1B | P53609 | 10/20 | 0.31 |
| ▸ | APLNR | P35414 | 1/20 | 0.31 |
| ▸ | NPY1R | P25929 | 1/20 | 0.30 |
| ▸ | NPY4R | P50391 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL285822 | 0.93 | FNTA (0.35) | CTSLCTSSCTSKCTSHFNTA | |
| Arginine SCHEMBL8512347 | 0.88 | FNTA (0.37) | CTSLCTSSCTSKCTSHFNTA | |
| Arginine SCHEMBL23362144 | 0.88 | FNTA (0.37) | CTSLCTSSCTSKCTSHFNTA | |
| Histidine SCHEMBL285813 | 0.87 | GSR (0.33) | — | |
| Arginine SCHEMBL2720905 | 0.85 | NPY1R (0.31) | NPY1RNPY4R | |
| SCHEMBL17363643 | 0.84 | FNTA (0.39) | CTSLCTSSCTSKCTSHFNTA | |
| Threonine SCHEMBL1964086 | 0.83 | FNTA (0.35) | FNTAFNTBPGGT1BNPY1RNPY4R | |
| Leucine SCHEMBL10439243 | 0.82 | APLNR (0.32) | APLNR | |
| Histidine SCHEMBL5502744 | 0.81 | NPY4R (0.31) | APLNRNPY1RNPY4R | |
| Arginine SCHEMBL27607779 | 0.81 | APLNR (0.36) | CTSLCTSSCTSKCTSHFNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120135931-A1 | METHOD OF MODIFYING SERINE PROTEASE INHIBITORS | NATURAL ENVIRONMENT RESEARCH COUNCIL (GB) | 2012-05-31 | — | — | US | disclosed |