Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.39 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.39 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.39 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.39 |
| ▸ | STIM2 | Q9P246 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | GPR6 | P46095 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2858515 | 0.91 | MAPT (0.44) | MAPTTRPC3ORAI1TRPC1STIM1 | |
| SCHEMBL2853465 | 0.89 | RAB9A (0.44) | MAPTTRPC3ORAI1TRPC1STIM1 | |
| SCHEMBL2852353 | 0.87 | RAB9A (0.44) | MAPTTRPC3ORAI1TRPC1STIM1 | |
| SCHEMBL2850694 | 0.86 | MAPT (0.41) | MAPTTRPC3ORAI1TRPC1STIM1 | |
| SCHEMBL2850809 | 0.86 | MAPT (0.43) | MAPTTRPC3ORAI1TRPC1STIM1 | |
| SCHEMBL2857582 | 0.85 | MAPT (0.42) | MAPTTRPC3ORAI1TRPC1STIM1 | |
| SCHEMBL2853258 | 0.84 | NPY5R (0.45) | MAPTTRPC3ORAI1TRPC1STIM1 | |
| SCHEMBL2852244 | 0.84 | MAPT (0.48) | MAPTTRPC3ORAI1TRPC1STIM1 | |
| SCHEMBL2859508 | 0.84 | CYP1A2 (0.46) | MAPTTRPC3ORAI1TRPC1STIM1 | |
| SCHEMBL2860489 | 0.84 | RXFP1 (0.45) | MAPTTRPC3ORAI1TRPC1STIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |