Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | GPR6 | P46095 | 1/20 | 0.39 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.39 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.39 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.39 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.39 |
| ▸ | STIM2 | Q9P246 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2852353 | 0.92 | RAB9A (0.44) | MAPTGPR6TRPC1TRPC3STIM1 | |
| SCHEMBL2860522 | 0.90 | MAPT (0.48) | MAPTCCR1RAB9AALDH1A1MEN1 | |
| SCHEMBL2853465 | 0.90 | RAB9A (0.44) | MAPTGPR6TRPC1TRPC3STIM1 | |
| SCHEMBL2850834 | 0.89 | NTRK1 (0.45) | MAPTRAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL2850809 | 0.87 | MAPT (0.43) | MAPTTRPC1TRPC3STIM1ORAI1 | |
| SCHEMBL2852552 | 0.87 | MEN1 (0.51) | MAPTPDK1PDK2PDK3PDK4 | |
| SCHEMBL2854533 | 0.87 | MEN1 (0.46) | MAPTPDK1PDK2PDK3PDK4 | |
| SCHEMBL2859712 | 0.86 | CA1 (0.45) | MAPTACHESMN1; SMN2 | |
| SCHEMBL2853258 | 0.85 | NPY5R (0.45) | MAPTTRPC1TRPC3STIM1ORAI1 | |
| SCHEMBL2859508 | 0.85 | CYP1A2 (0.46) | MAPTGPR6TRPC1TRPC3STIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |