Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 6/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.38 |
| ▸ | HTR1A | P08908 | 6/20 | 0.35 |
| ▸ | HTR3A | P46098 | 6/20 | 0.35 |
| ▸ | HTR7 | P34969 | 5/20 | 0.35 |
| ▸ | HTR2B | P41595 | 5/20 | 0.35 |
| ▸ | HTR6 | P50406 | 5/20 | 0.35 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | HTR1D | P28221 | 4/20 | 0.31 |
| ▸ | HTR2A | P28223 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28106504 | 0.80 | — | — | |
| SCHEMBL261863 | 0.80 | GFER (0.39) | USP2ALDH1A1TSHRNPC1RAB9A | |
| Piperazine SCHEMBL28080108 | 0.79 | USP2 (0.38) | CHRNB2CHRNA4HTR1AHTR3AHTR7 | |
| SCHEMBL1478216 | 0.78 | NPC1 (0.41) | USP2ALDH1A1TSHRNPC1RAB9A | |
| SCHEMBL4491073 | 0.76 | ADRB1 (0.48) | HTR1AHTR3AHTR7HTR2BHTR6 | |
| SCHEMBL28697522 | 0.73 | ADRB1 (0.32) | HTR1AHTR6HTR2AHTR2C | |
| SCHEMBL2051022 | 0.71 | HTR3A (0.57) | CHRNB2CHRNA4HTR1AHTR3AHTR7 | |
| SCHEMBL7189439 | 0.69 | HDAC8 (0.34) | — | |
| SCHEMBL3833537 | 0.68 | LMNA (0.48) | USP2ALDH1A1TSHRNPC1RAB9A | |
| SCHEMBL21047844 | 0.68 | NPC1 (0.33) | NPC1RAB9AGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109071532-B | FGFR4 inhibitor, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2021-04-27 | — | — | CN | disclosed |