Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 8/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 7/20 | 0.62 |
| ▸ | PRKCG | P05129 | 7/20 | 0.62 |
| ▸ | PRKCB | P05771 | 7/20 | 0.62 |
| ▸ | PRKCA | P17252 | 7/20 | 0.62 |
| ▸ | PRKCH | P24723 | 7/20 | 0.62 |
| ▸ | PRKCI | P41743 | 7/20 | 0.62 |
| ▸ | PRKCE | Q02156 | 7/20 | 0.62 |
| ▸ | PRKCQ | Q04759 | 7/20 | 0.62 |
| ▸ | PRKCD | Q05655 | 7/20 | 0.62 |
| ▸ | PRKD1 | Q15139 | 7/20 | 0.62 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.62 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.62 |
| ▸ | PRKACA | P17612 | 5/20 | 0.62 |
| ▸ | PRKACG | P22612 | 5/20 | 0.62 |
| ▸ | PRKACB | P22694 | 5/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL115053 | 0.87 | CYP3A4 (0.56) | PRKCZPRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL29546384 | 0.87 | CYP3A4 (0.56) | PRKCZPRKD3PRKCGPRKCBPRKCA | |
| Hydrochloric Acid SCHEMBL987360 | 0.85 | LMNA (0.57) | PRKCZPRKD3PRKCGPRKCBPRKCA | |
| Hydrochloric Acid SCHEMBL29469852 | 0.85 | LMNA (0.57) | PRKCZPRKD3PRKCGPRKCBPRKCA | |
| Fasudil SCHEMBL6269832 | 0.77 | ROCK2 (1.00) | PRKCZPRKD3PRKCGPRKCBPRKCA | |
| Fasudil SCHEMBL29381868 | 0.77 | ROCK2 (1.00) | PRKCZPRKD3PRKCGPRKCBPRKCA | |
| Fasudil SCHEMBL4674 | 0.77 | ROCK2 (1.00) | PRKCZPRKD3PRKCGPRKCBPRKCA | |
| Fasudil SCHEMBL29362990 | 0.77 | ROCK2 (1.00) | PRKCZPRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL28592488 | 0.77 | PRKD3 (0.49) | PRKCZPRKD3PRKCGPRKCBPRKCA | |
| Fasudil SCHEMBL678615 | 0.76 | ROCK2 (0.98) | PRKCZPRKD3PRKCGPRKCBPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112986409-A | Method for detecting isoquinoline sulfonate genotoxic impurities in fasudil | 南京亿华药业有限公司 | 2021-06-18 | — | — | CN | disclosed |