Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.31 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.31 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12464949 | 0.87 | — | — | |
| Bicarbonate SCHEMBL6507595 | 0.85 | CHRM1 (0.42) | CA2MAPK1HDAC1HDAC2CHRM1 | |
| Bicarbonate SCHEMBL8027594 | 0.79 | GPR84 (0.45) | CA2MAPK1ACE2 | |
| Bicarbonate SCHEMBL3240516 | 0.74 | CTSK (0.36) | FFAR3CA2MAPK1HDAC1HDAC2 | |
| Bicarbonate SCHEMBL1157519 | 0.74 | MAPT (0.33) | FFAR3CA2MAPK1HDAC1HDAC2 | |
| Bicarbonate SCHEMBL208216 | 0.74 | MAPT (0.33) | FFAR3CA2MAPK1HDAC1HDAC2 | |
| Bicarbonate SCHEMBL3240523 | 0.74 | CTSK (0.36) | FFAR3CA2MAPK1HDAC1HDAC2 | |
| SCHEMBL17706577 | 0.74 | — | — | |
| SCHEMBL518870 | 0.73 | — | — | |
| Bicarbonate SCHEMBL23581989 | 0.72 | CA1 (0.32) | CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111138610-B | High-impact-resistance high-heat-resistance ASA resin and preparation method and application thereof | 广州熵能创新材料股份有限公司 | 2022-12-27 | — | — | CN | disclosed |
| CN-107267076-B | Method for manufacturing anisotropic conductive film and anisotropic conductive film | 迪睿合电子材料有限公司 | 2021-06-29 | — | — | CN | disclosed |
| CN-111138610-A | High-impact-resistance high-heat-resistance ASA resin and preparation method and application thereof | 广州熵能创新材料股份有限公司 | 2020-05-12 | — | — | CN | disclosed |