Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL1157519 | 1.00 | MAPT (0.33) | MAPTTSHRFFAR3TP53CA2 | |
| Bicarbonate SCHEMBL2774047 | 0.97 | MAPT (0.33) | MAPTTSHRFFAR3TP53CA2 | |
| SCHEMBL124121 | 0.88 | — | — | |
| Benzene SCHEMBL190107 | 0.86 | TSHR (0.35) | MAPTTSHR | |
| Bicarbonate SCHEMBL28900979 | 0.82 | CA2 (0.42) | MAPTTSHRCA2MAPK1TDP1 | |
| Bicarbonate SCHEMBL27232679 | 0.80 | TSHR (0.35) | MAPTTSHRFFAR3TP53CA2 | |
| Bicarbonate SCHEMBL29135929 | 0.78 | FFAR3 (0.33) | MAPTTSHRFFAR3TP53CA2 | |
| Bicarbonate SCHEMBL28959796 | 0.78 | FFAR3 (0.33) | MAPTTSHRFFAR3TP53CA2 | |
| Bicarbonate SCHEMBL28587396 | 0.74 | FFAR3 (0.35) | TSHRFFAR3CA2MAPK1CHRM1 | |
| SCHEMBL25435789 | 0.72 | MAPT (0.41) | MAPTTSHRFFAR3TP53CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1684 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250353967-A1 | CURABLE SILOXANE RESIN COMPOSITION AND FILM INCLUDING THE SAME | KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2025-11-20 | — | — | US | claimed |
| US-12331164-B2 | Curable siloxane resin composition | KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2025-06-17 | — | — | US | claimed |
| EP-3570358-B1 | ELECTRODE ASSEMBLY FOR SOLID STATE BATTERY AND METHOD FOR MANUFACTURING THE SAME | LG ENERGY SOLUTION LTD (KR) | 2024-11-20 | — | — | EP | claimed |
| US-11794161-B1 | Reduced permeability microcapsules | TRUCAPSOL, LLC (US) | 2023-10-24 | — | — | US | claimed |
| WO-2023140096-A1 | MODIFIED ALIPHATIC POLYESTER-BASED RESIN AND COMPOSITION OR MOLDED BODY THEREOF | 株式会社カネカ | 2023-07-27 | — | — | WO | claimed |
| WO-2023140097-A1 | METHOD FOR MANUFACTURING MODIFIED ALIPHATIC OR ALIPHATIC AROMATIC THERMOPLASTIC POLYESTER RESIN | 株式会社カネカ | 2023-07-27 | — | — | WO | claimed |
| CN-116249721-A | Composition comprising at least one organic peroxide, at least one emulsifier, and hydrogen peroxide | 阿科玛法国公司 | 2023-06-09 | — | — | CN | claimed |
| US-20230078587-A1 | CURABLE SILOXANE RESIN COMPOSITION | KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2023-03-16 | — | — | US | claimed |
| US-11584814-B2 | Ethylene-vinyl acetate copolymer and preparation method thereof | LG CHEM, LTD. | 2023-02-21 | — | — | US | claimed |
| WO-2022117389-A1 | METHOD FOR PRODUCING A TERMINAL-FUNCTIONAL POLYMER | BASF SE (DE) | 2022-06-09 | — | — | WO | claimed |
| US-4835233-A | Liquid polymerizable compositions for the production of substitutes for optical glasses | ENICHEM SINTESI S.P.A. (IT) | 1989-05-30 | — | — | US | claimed |
| EP-0309088-A2 | In-mold coating powder containing 1,1'-di(t-butylperoxy)-3,3,5-trimethylcyclohexane as an initiator. | MORTON INTERNATIONAL, INC. (US) | 1989-03-29 | — | — | EP | claimed |
| EP-0299025-A1 | IMPROVED HAIR TREATING RESINS. | GAF CORP (US) | 1989-01-18 | — | — | EP | claimed |
| WO-1988005442-A1 | IMPROVED HAIR TREATING RESINS | GAF CORPORATION (US) | 1988-07-28 | — | — | WO | claimed |
| US-4739014-A | USING FREE RADICAL CATALYST | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1988-04-19 | — | — | US | claimed |
| US-4689379-A | TERPOLYMER OF VINYL ESTER, ALKYL MALEATE HALF ESTER AND ACRYLATE OR METHACRYLATE ESTER | GAF CORPORATION (US) | 1987-08-25 | — | — | US | claimed |
| EP-0227178-A2 | Liquid, polymerizable composition for the production of substitutes for optical glasses | ENICHEM SYNTHESIS S.p.A. (IT) | 1987-07-01 | — | — | EP | claimed |
| US-4396527-A | Aqueous emulsions of organic peroxides | NIPPON OIL AND FATS CO., LTD. (JP) | 1983-08-02 | — | — | US | claimed |
| US-4039595-A | Copolymers of ethylene and hexafluoropropene | PENNWALT CORPORATION (US) | 1977-08-02 | — | — | US | claimed |
| US-4008175-A | Organic acid anhydride-peroxydicarbonate composition | PPG INDUSTRIES, INC. (US) | 1977-02-15 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11794161-B1 | Reduced permeability microcapsules | CHMP4B, NSF, ACR | MAPT 1409/4885TSHR 3004/4885FFAR3 1483/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.