Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 4/20 | 0.41 |
| ▸ | HTR2C | P28335 | 4/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17634311 | 0.81 | HTR6 (0.41) | HSP90AA1HSP90AB1DRD2DRD4DRD3 | |
| SCHEMBL17634271 | 0.78 | JAK3 (0.42) | HTR6PIK3CDPIK3CAPIK3CB | |
| SCHEMBL17634298 | 0.78 | CKS1B (0.45) | LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL27630897 | 0.73 | HTR1A (0.51) | POLBHTR2AHTR2CHSP90AA1HSP90AB1 | |
| SCHEMBL14553409 | 0.71 | NOS1 (0.52) | METAP2HTT | |
| SCHEMBL31148280 | 0.71 | NOS1 (0.52) | METAP2HTT | |
| SCHEMBL25365607 | 0.71 | TDO2 (0.58) | POLBHTR2AHTR2CHSP90AA1HSP90AB1 | |
| SCHEMBL30485711 | 0.71 | TDO2 (0.58) | POLBHTR2AHTR2CHSP90AA1HSP90AB1 | |
| SCHEMBL30860972 | 0.69 | NOS1 (0.46) | METAP2DRD4HTT | |
| SCHEMBL15687490 | 0.69 | NOS1 (0.46) | METAP2DRD4HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113166139-A | Pyrrolo [2,3-b ] pyridines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-07-23 | — | — | CN | disclosed |