Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | CCR1 | P32246 | 14/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2857075 | 0.91 | P2RX1 (0.57) | LMNAHPGDCCR1HSP90AA1MAPT | |
| SCHEMBL2859858 | 0.90 | CCR1 (0.52) | LMNAHPGDCCR1CYP1A2CYP3A4 | |
| SCHEMBL2850536 | 0.88 | CCR1 (0.52) | LMNAHPGDCCR1 | |
| SCHEMBL2859933 | 0.87 | CCR1 (0.80) | LMNAHPGDCCR1MEN1PLA2G1B | |
| SCHEMBL2854432 | 0.87 | CCR1 (0.68) | LMNAHPGDCCR1MEN1PLA2G1B | |
| SCHEMBL2852539 | 0.84 | LMNA (0.52) | LMNAHPGDCCR1MEN1PLA2G1B | |
| SCHEMBL2856467 | 0.83 | P2RX7 (0.51) | LMNAHPGDCCR1HSP90AA1MAPT | |
| SCHEMBL2860195 | 0.82 | CCR1 (0.70) | LMNAHPGDCCR1NPSR1 | |
| SCHEMBL2859642 | 0.82 | CCR1 (0.73) | HPGDCCR1MAPT | |
| SCHEMBL2855376 | 0.81 | CCR1 (0.60) | LMNAHPGDCCR1MEN1PLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |