Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 4/20 | 0.40 |
| ▸ | CDK2 | P24941 | 4/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2858190 | 0.91 | MEN1 (0.38) | CCNE1CDK2CYP2C19SMN1; SMN2NPC1 | |
| SCHEMBL2854222 | 0.89 | SMN1; SMN2 (0.40) | CCNE1CDK2CYP2C19SMN1; SMN2NPC1 | |
| SCHEMBL2858043 | 0.87 | CCNE1 (0.40) | CCNE1CDK2CYP2C19SMN1; SMN2NPC1 | |
| SCHEMBL973019 | 0.86 | BTK (0.38) | CCNE1CDK2SMPD3BTKHRH3 | |
| SCHEMBL2862996 | 0.83 | CCNE1 (0.38) | CCNE1CDK2CYP2C19SMN1; SMN2NPC1 | |
| SCHEMBL2855060 | 0.83 | ALDH1A1 (0.43) | SMN1; SMN2MEN1KMT2AALDH1A1SMPD3 | |
| SCHEMBL2853786 | 0.80 | LMNA (0.38) | CYP2C19SMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL4698213 | 0.80 | DRD2 (0.40) | CCNE1CDK2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL973545 | 0.80 | BTK (0.45) | SMPD3BTKHRH3 | |
| SCHEMBL974804 | 0.80 | SMN1; SMN2 (0.41) | CYP2C19SMN1; SMN2NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968957-B1 | SUBSTITUTED THIAZOLES AND THEIR USE FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2010-01-20 | — | — | EP | claimed |