Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 4/20 | 0.38 |
| ▸ | CDK2 | P24941 | 4/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.36 |
| ▸ | CCR2 | P41597 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2856320 | 0.89 | CHRNA7 (0.40) | CCNE1CDK2BTKKMT2ACHRNA7 | |
| SCHEMBL975864 | 0.86 | BTK (0.38) | BTKCHRNA7HRH3ACKR3 | |
| SCHEMBL2858043 | 0.85 | CCNE1 (0.40) | CCNE1CDK2BTKCYP2C19CTDSP1 | |
| SCHEMBL2859083 | 0.83 | CCNE1 (0.40) | CCNE1CDK2BTKCYP2C19CTDSP1 | |
| SCHEMBL2856121 | 0.83 | PAK1 (0.40) | BTKMEN1KMT2AALDH1A1CHRNA7 | |
| SCHEMBL2858190 | 0.80 | MEN1 (0.38) | CCNE1CDK2BTKCYP2C19CTDSP1 | |
| SCHEMBL973764 | 0.80 | BTK (0.45) | BTKCHRNA7HRH3ACKR3 | |
| SCHEMBL974821 | 0.80 | HRH3 (0.38) | BTKCHRNA7HRH3ACKR3 | |
| SCHEMBL974009 | 0.79 | RAB9A (0.39) | CCNE1CDK2BTKRAB9AHRH3 | |
| SCHEMBL971211 | 0.79 | CHRM5 (0.41) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968957-B1 | SUBSTITUTED THIAZOLES AND THEIR USE FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2010-01-20 | — | — | EP | claimed |