Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2853091 | 0.83 | MAPT (0.49) | CYP3A4POLBMAPTSMN1; SMN2CCR1 | |
| SCHEMBL2858436 | 0.83 | MEN1 (0.46) | CYP3A4MAPTSMN1; SMN2HTTKDM4E | |
| SCHEMBL2862815 | 0.83 | DRD2 (0.41) | CYP3A4POLBMAPTSMN1; SMN2CCR1 | |
| SCHEMBL2854457 | 0.82 | CYP3A4 (0.43) | CYP3A4POLBMAPTSMN1; SMN2HTT | |
| SCHEMBL2854852 | 0.81 | ABCB1 (0.49) | SMN1; SMN2HTTCCR1ABCB1KDM4E | |
| SCHEMBL2853193 | 0.79 | MAPT (0.43) | MAPTSMN1; SMN2CCR1ABCB1 | |
| SCHEMBL2857729 | 0.78 | CNR1 (0.53) | MAPTKDM4E | |
| SCHEMBL2850524 | 0.78 | MAPT (0.43) | CYP3A4MAPTSMN1; SMN2ACHENR3C1 | |
| SCHEMBL2860795 | 0.77 | KMT2A (0.46) | CYP3A4POLBMAPTSMN1; SMN2ACHE | |
| SCHEMBL2852244 | 0.77 | MAPT (0.48) | POLBMAPTSMN1; SMN2ACHENR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |