SCHEMBL2859451

SCHEMBL2859451

CCCC(Cl)OC(=O)C(c1ccccc1)c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KLK7 P49862 7/20 0.50
CYP1A2 P05177 2/20 0.48
CYP2D6 P10635 2/20 0.48
LMNA P02545 1/20 0.48
CHRM1 P11229 4/20 0.47
CHRM3 P20309 4/20 0.47
CHRM2 P08172 3/20 0.47
CHRM4 P08173 3/20 0.47
CYP3A4 P08684 3/20 0.47
ALDH1A1 P00352 3/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
POLB P06746 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.44
KMT2A Q03164 1/20 0.43
HSD17B10 Q99714 1/20 0.43
TSHR P16473 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL359759 0.81 KLK7 (0.57) KLK7CYP1A2CYP2D6LMNACHRM1
SCHEMBL2865464 0.81 CHRM1 (0.50) KLK7CYP1A2CYP2D6LMNACHRM1
SCHEMBL359760 0.81 KLK7 (0.57) KLK7CYP1A2CYP2D6LMNACHRM1
SCHEMBL2864140 0.81 KLK7 (0.50) KLK7CYP1A2CYP2D6LMNACHRM1
SCHEMBL2864946 0.78 KLK7 (0.57) KLK7CYP1A2CYP2D6LMNACHRM1
SCHEMBL28125624 0.77 NAAA (0.47) KLK7LMNACYP3A4ALDH1A1SMN1; SMN2
SCHEMBL27504436 0.77 LMNA (0.51) CYP1A2CYP2D6LMNAALDH1A1SMN1; SMN2
SCHEMBL360673 0.75 KLK7 (0.59) KLK7CYP1A2CYP2D6LMNACHRM1
SCHEMBL360674 0.75 KLK7 (0.59) KLK7CYP1A2CYP2D6LMNACHRM1
SCHEMBL9860577 0.75 ALDH1A1 (0.50) LMNACYP3A4ALDH1A1L3MBTL1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1795581-B1 LUBRICATING OIL COMPOSITION CONTAINING ACRYLIC POLYMER KURARAY CO (JP) 2018-09-19 EP disclosed
US-7718588-B2 Lubricating oil additive containing acrylic polymer and lubricating oil compositions KURARAY CO., LTD. (JP) 2010-05-18 US disclosed
US-20080058234-A1 Lubricating Oil Additive Containing Acrylic Polymer and Lubricating Oil Compositions KURARAY CO., LTD. (JP) 2008-03-06 US disclosed
EP-1795581-A1 LUBRICATING OIL ADDITIVE CONTAINING ACRYLIC POLYMER AND LUBRICATING OIL COMPOSITIONS KURARAY CO., LTD. (JP) 2007-06-13 EP disclosed