Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | MMP13 | P45452 | 3/20 | 0.37 |
| ▸ | MMP1 | P03956 | 2/20 | 0.37 |
| ▸ | MMP9 | P14780 | 2/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP7 | P09237 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | STS | P08842 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28595291 | 1.00 | HTR6 (0.39) | HTR6BCHEMMP13MMP1MMP9 | |
| SCHEMBL28590708 | 0.90 | NPC1 (0.35) | HTR6NPC1RAB9A | |
| SCHEMBL28595288 | 0.81 | HTR6 (0.43) | HTR6BCHEMMP13MMP1MMP9 | |
| SCHEMBL28917545 | 0.79 | L3MBTL1 (0.34) | NPC1RAB9A | |
| SCHEMBL28916708 | 0.79 | NAMPT (0.36) | JAK2JAK1METMEN1KMT2A | |
| SCHEMBL28916717 | 0.79 | SMN1; SMN2 (0.33) | NPC1RAB9A | |
| SCHEMBL1935242 | 0.78 | HTR6 (0.43) | HTR6BCHEMMP13MMP1MMP9 | |
| SCHEMBL1934902 | 0.78 | HTR6 (0.43) | HTR6BCHEMMP13MMP1MMP9 | |
| SCHEMBL28589631 | 0.77 | USP30 (0.44) | HTR6BCHEMMP13MMP1MMP9 | |
| SCHEMBL1935238 | 0.77 | USP30 (0.44) | HTR6BCHEMMP13MMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109053742-B | Novel tricyclic compounds | ABBVIE 公司 | 2021-06-15 | — | — | CN | disclosed |