Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 4/20 | 0.36 |
| ▸ | MAOB | P27338 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11133458 | 0.78 | LTA4H (0.44) | TSHRALDH1A1LMNACYP1A2CYP2D6 | |
| SCHEMBL8846449 | 0.78 | LTA4H (0.44) | TSHRALDH1A1LMNACYP1A2CYP2D6 | |
| SCHEMBL3199580 | 0.75 | KMT2A (0.41) | CHRNB2CHRNB4CHRNA3CHRNA4TSHR | |
| SCHEMBL27750659 | 0.73 | MAOA (0.41) | TSHRALDH1A1LMNATP53SMN1; SMN2 | |
| SCHEMBL5669517 | 0.72 | NPC1 (0.44) | NPC1TSHRALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL28776425 | 0.70 | TSHR (0.44) | NPC1TSHRALDH1A1LMNATP53 | |
| SCHEMBL11856183 | 0.70 | NPC1 (0.42) | NPC1TSHRALDH1A1GLAHTT | |
| SCHEMBL6632940 | 0.70 | CHRNB2 (0.40) | NPC1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL6659379 | 0.70 | CHRNB2 (0.40) | NPC1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL17666033 | 0.69 | ALDH1A1 (0.45) | TSHRALDH1A1LMNATP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247743-A2 | MODIFIED LEPTIN POLYPEPTIDES AND THEIR USES | AMBRX, INC. (US) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009100255-A2 | MODIFIED LEPTIN POLYPEPTIDES AND THEIR USES | AMBRX, INC. (US) | 2009-08-13 | — | — | WO | disclosed |