Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29303422 | 0.78 | HDAC8 (0.34) | HDAC8 | |
| SCHEMBL28591652 | 0.77 | GPR119 (0.44) | IRAK4 | |
| SCHEMBL25912147 | 0.71 | TLR8 (0.41) | IRAK4AXLTLR8HRH4GAA | |
| SCHEMBL25911938 | 0.71 | TLR8 (0.44) | IRAK4AXLTLR8HRH4GAA | |
| SCHEMBL31713084 | 0.71 | ADORA3 (0.36) | LRRK2 | |
| SCHEMBL544118 | 0.71 | BACE1 (0.40) | AXLHDAC8 | |
| SCHEMBL28597609 | 0.69 | ALOX15 (0.46) | KDM5AGAASMN1; SMN2 | |
| SCHEMBL15344954 | 0.68 | IRAK4 (0.44) | IRAK4AXLTLR8GAASMN1; SMN2 | |
| SCHEMBL31544121 | 0.68 | DRD2 (0.43) | HRH4 | |
| SCHEMBL26654971 | 0.68 | IRAK4 (0.51) | IRAK4TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113166139-A | Pyrrolo [2,3-b ] pyridines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-07-23 | — | — | CN | disclosed |