Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 2/20 | 0.50 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.50 |
| ▸ | IKBKB | O14920 | 8/20 | 0.45 |
| ▸ | CHUK | O15111 | 7/20 | 0.45 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.45 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12585067 | 0.84 | XDH (0.64) | XDHSLC22A12IKBKBCHUKIMPDH2 | |
| SCHEMBL3707241 | 0.76 | IMPDH2 (0.50) | XDHSLC22A12IKBKBCHUKIMPDH2 | |
| SCHEMBL12585069 | 0.76 | XDH (0.46) | XDHSLC22A12IKBKBCHUK | |
| SCHEMBL28617336 | 0.75 | IKBKB (0.44) | XDHSLC22A12IKBKBCHUKRIPK1 | |
| SCHEMBL28601707 | 0.73 | XDH (0.46) | XDHSLC22A12IKBKBCHUKIMPDH2 | |
| SCHEMBL30088006 | 0.73 | XDH (0.46) | XDHSLC22A12IKBKBCHUKIMPDH2 | |
| SCHEMBL8530077 | 0.73 | IMPDH2 (0.50) | XDHSLC22A12IKBKBCHUKIMPDH2 | |
| SCHEMBL988243 | 0.73 | IMPDH2 (0.50) | XDHSLC22A12IKBKBCHUKIMPDH2 | |
| SCHEMBL16636645 | 0.73 | IMPDH2 (0.50) | XDHSLC22A12IKBKBCHUKIMPDH2 | |
| SCHEMBL21920740 | 0.70 | IMPDH2 (0.44) | XDHSLC22A12IKBKBCHUKIMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113015526-A | Spirocyclic 2, 3-dihydro-7-azaindole compounds and uses thereof | 豪夫迈·罗氏有限公司 | 2021-06-22 | — | — | CN | disclosed |