Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RECQL | P46063 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | GBA1 | P04062 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | CASP7 | P55210 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | CCNC | P24863 | 1/20 | 0.53 |
| ▸ | CDK8 | P49336 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10330604 | 0.85 | MAPT (0.57) | POLBRAB9AALDH1A1NPC1MAPT | |
| SCHEMBL7528507 | 0.84 | SMN1; SMN2 (0.67) | RAB9AALDH1A1NPC1TSHRMAPT | |
| SCHEMBL11750528 | 0.82 | POLB (0.63) | POLBRAB9AALDH1A1NPC1RECQL | |
| SCHEMBL10330128 | 0.81 | MAPT (0.54) | POLBRAB9AALDH1A1NPC1MAPT | |
| SCHEMBL6918008 | 0.80 | POLB (0.66) | POLBRAB9AALDH1A1NPC1RECQL | |
| SCHEMBL12808274 | 0.80 | POLB (0.44) | POLBRAB9AALDH1A1NPC1RECQL | |
| SCHEMBL3012871 | 0.79 | POLB (0.70) | POLBRAB9AALDH1A1NPC1TSHR | |
| SCHEMBL4113264 | 0.78 | IDH1 (0.69) | POLBRAB9AALDH1A1NPC1MAPT | |
| SCHEMBL26463986 | 0.78 | ALDH1A1 (0.62) | POLBRAB9AALDH1A1NPC1RECQL | |
| SCHEMBL4112716 | 0.78 | RAB9A (0.73) | POLBRAB9AALDH1A1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108558756-B | 2-aryl-2, 3-dihydro-4 (1H) -quinolinone semicarbazone compound and application thereof | 沈阳药科大学 | 2021-08-03 | — | — | CN | disclosed |