Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 2/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.49 |
| ▸ | PLK1 | P53350 | 5/20 | 0.49 |
| ▸ | EGFR | P00533 | 7/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | ROS1 | P08922 | 1/20 | 0.41 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23606892 | 0.86 | MAPK10 (0.48) | MAPK10FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL30045147 | 0.86 | MAPK10 (0.48) | MAPK10FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL23606893 | 0.86 | FGFR1 (0.51) | MAPK10FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL28604830 | 0.77 | SLC2A1 (0.59) | FGFR1FGFR2FGFR4FGFR3PLK1 | |
| SCHEMBL1231927 | 0.76 | MAPK10 (0.75) | MAPK10FGFR1FGFR3PLK1EGFR | |
| SCHEMBL12901057 | 0.76 | MAPK10 (0.75) | MAPK10FGFR1FGFR3PLK1EGFR | |
| SCHEMBL28537291 | 0.76 | PLK1 (0.63) | FGFR1FGFR2FGFR4FGFR3PLK1 | |
| SCHEMBL28535201 | 0.75 | MAPK10 (0.51) | MAPK10FGFR1FGFR4EGFRALK | |
| SCHEMBL25139771 | 0.75 | PLK1 (0.60) | FGFR1FGFR2FGFR4FGFR3PLK1 | |
| SCHEMBL30043654 | 0.75 | PLK1 (0.60) | FGFR1FGFR2FGFR4FGFR3PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113087671-B | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2022-10-21 | — | — | CN | disclosed |
| CN-113087671-A | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2021-07-09 | — | — | CN | disclosed |