Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23003874 | 0.80 | NOTUM (0.41) | SIRT1ALDH1A1KMT2AMEN1POLB | |
| SCHEMBL21382123 | 0.69 | PTGS1 (0.39) | ALDH1A1KMT2AMEN1POLBTP53 | |
| SCHEMBL17667647 | 0.68 | KIF11 (0.33) | ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL18469507 | 0.65 | KDM4E (0.37) | ALDH1A1KMT2AMEN1GAA | |
| SCHEMBL26938748 | 0.65 | KMT2A (0.41) | SIRT1ALDH1A1KMT2AMEN1NISCH | |
| SCHEMBL24377955 | 0.65 | SIRT1 (0.52) | SIRT1KMT2AMEN1TDP1SIRT2 | |
| SCHEMBL17667644 | 0.62 | HPGD (0.40) | ALDH1A1KMT2AMEN1POLBMAPK1 | |
| SCHEMBL7822473 | 0.60 | POLB (0.47) | SIRT1ALDH1A1KMT2AMEN1NISCH | |
| SCHEMBL30869643 | 0.59 | MAPT (0.46) | ALDH1A1TP53MAPTHTT | |
| SCHEMBL28598365 | 0.59 | L3MBTL1 (0.59) | ALDH1A1KMT2AMEN1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113166062-A | 8-aminoisoquinoline compounds and uses thereof | 豪夫迈·罗氏有限公司 | 2021-07-23 | — | — | CN | disclosed |