SCHEMBL28601570

SCHEMBL28601570

FC(F)(F)COc1cc(Cl)ccn1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 2/20 0.40
L3MBTL1 Q9Y468 3/20 0.39
MAPT P10636 4/20 0.39
SMN1; SMN2 Q16637 1/20 0.38
ALDH1A1 P00352 2/20 0.36
KDM4E B2RXH2 1/20 0.36
MEN1 O00255 1/20 0.36
USP2 O75604 1/20 0.36
HSP90AA1 P07900 1/20 0.36
HSP90AB1 P08238 1/20 0.36
THRB P10828 1/20 0.36
G6PD P11413 1/20 0.36
ALOX15 P16050 1/20 0.36
CASP1 P29466 1/20 0.36
KMT2A Q03164 1/20 0.36
HSD17B10 Q99714 1/20 0.36
KDM2B Q8NHM5 1/20 0.35
KDM4C Q9H3R0 1/20 0.35
HDAC1 Q13547 3/20 0.34
HDAC6 Q9UBN7 3/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31507846 0.82 S1PR4 (0.31) EPHX2
SCHEMBL14349236 0.81 NUDT1 (0.50) L3MBTL1MAPTALDH1A1
SCHEMBL31507808 0.80 EPHX2 (0.32) EPHX2L3MBTL1MAPTALDH1A1
SCHEMBL31507807 0.80 EPHX2 (0.32) EPHX2L3MBTL1MAPTALDH1A1
SCHEMBL4182663 0.79 MAPT (0.46) EPHX2L3MBTL1MAPTSMN1; SMN2ALDH1A1
SCHEMBL17253049 0.78 L3MBTL1 (0.42) EPHX2L3MBTL1MAPTSMN1; SMN2ALDH1A1
SCHEMBL10174370 0.78 RXRA (0.44) EPHX2L3MBTL1MAPTSMN1; SMN2ALDH1A1
SCHEMBL109903 0.78 ALDH1A1 (0.48) EPHX2L3MBTL1MAPTSMN1; SMN2ALDH1A1
SCHEMBL3359088 0.78 HRH4 (0.40) EPHX2L3MBTL1MAPTSMN1; SMN2ALDH1A1
SCHEMBL29560184 0.78 HRH4 (0.40) EPHX2L3MBTL1MAPTSMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4735423-A1 KV7 MODULATORS Saniona A/S (DK) 2026-05-06 EP disclosed
WO-2025003343-A1 KV7 MODULATORS SANIONA A/S (DK) 2025-01-02 WO disclosed
CN-113164461-A Heterocyclic derivatives as Nav1.7 and Nav1.8 blockers 拉夸里亚创药株式会社 2021-07-23 CN disclosed