SCHEMBL28601678

SCHEMBL28601678

Cc1nc(-c2cncc(F)c2)sc1NC(=O)OC(C)Cl

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PIK3CG P48736 1/20 0.38
DYRK1A Q13627 5/20 0.37
ALDH1A1 P00352 2/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
GAA P10253 1/20 0.36
CYP1A2 P05177 3/20 0.36
CYP3A4 P08684 3/20 0.36
CYP2C19 P33261 2/20 0.36
PTGDR2 Q9Y5Y4 1/20 0.36
POLQ O75417 1/20 0.35
XIAP P98170 1/20 0.34
BIRC2 Q13490 1/20 0.34
HTT P42858 1/20 0.33
PIM1 P11309 1/20 0.33
ABL1 P00519 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C9 P11712 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13047720 0.83 DYRK1A (0.43) PIK3CGDYRK1AGAACYP1A2CYP3A4
SCHEMBL25405384 0.82 PIK3CG (0.44) PIK3CGDYRK1AALDH1A1MEN1KMT2A
SCHEMBL13048243 0.82 DYRK1A (0.41) PIK3CGDYRK1AMEN1KMT2ACYP1A2
SCHEMBL30617081 0.82 DYRK1A (0.41) PIK3CGDYRK1AMEN1KMT2ACYP1A2
SCHEMBL17629312 0.82 ALDH1A1 (0.47) PIK3CGDYRK1AALDH1A1MEN1KMT2A
SCHEMBL18569322 0.78 CYP1A2 (0.38) PIK3CGDYRK1AALDH1A1MEN1KMT2A
SCHEMBL18568993 0.78 PIK3CG (0.38) PIK3CGDYRK1ACYP1A2CYP3A4CYP2C19
SCHEMBL290519 0.77 DYRK1A (0.39) PIK3CGDYRK1ACYP1A2CYP3A4CYP2C19
SCHEMBL13047897 0.77 CYP1A2 (0.37) PIK3CGDYRK1AMEN1KMT2ACYP1A2
SCHEMBL13047738 0.76 LIPG (0.37) PIK3CGDYRK1ACYP1A2CYP3A4CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107001349-B Herbicidal pyrido/pyrimidothiazoles 先正达参股股份有限公司 2021-07-02 CN disclosed