SCHEMBL2860264

SCHEMBL2860264

C=C(C)c1cccc(C(C)CN=C=O)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GBA1 P04062 1/20 0.43
MIF P14174 1/20 0.35
PTGS1 P23219 3/20 0.34
PTGS2 P35354 3/20 0.34
MAPT P10636 2/20 0.34
CXCR1 P25024 2/20 0.34
CXCR2 P25025 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
HDAC4 P56524 1/20 0.34
HDAC2 Q92769 1/20 0.34
HDAC8 Q9BY41 1/20 0.34
RECQL P46063 1/20 0.34
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
LMNA P02545 1/20 0.34
CYP3A4 P08684 1/20 0.34
HPGD P15428 1/20 0.34
MAPK1 P28482 1/20 0.34
PMP22 Q01453 1/20 0.34
SLC22A6 Q4U2R8 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8762463 0.88 GBA1 (0.42) GBA1MIFPTGS1PTGS2MAPT
SCHEMBL9723603 0.87 GBA1 (0.36) GBA1CYP3A4
SCHEMBL8762460 0.83 GBA1 (0.39) GBA1MIFPTGS1PTGS2MAPT
SCHEMBL484032 0.83 MIF (0.40) MIFMAPTSMN1; SMN2HDAC4HDAC2
SCHEMBL8091278 0.82 MIF (0.45) MIF
SCHEMBL8761376 0.80 GBA1 (0.37) GBA1MIFPTGS1PTGS2MAPT
SCHEMBL5416148 0.78 GBA1 (0.38) GBA1MIFPTGS1PTGS2MAPT
SCHEMBL5165244 0.77 GBA1 (0.43) GBA1PTGS1PTGS2MAPTCXCR1
SCHEMBL8762863 0.76 GBA1 (0.35) GBA1SMN1; SMN2ALDH1A1LMNAHIF1A
SCHEMBL2511979 0.75 GBA1 (0.36) GBA1PTGS1PTGS2MAPTCXCR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 96 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1301565-A1 REAGENTS FOR HEAT ACTIVATED POLYMER CROSSLINKING NATIONAL STARCH AND CHEMICAL INVESTMENT HOLDING CORPORATION (US) 2003-04-16 EP claimed
EP-1290103-A1 RADIATION CURABLE FREE RADICALLY POLYMERIZED STAR-BRANCHED POLYMERS National Starch and Chemical Investment Holding Corporation (US) 2003-03-12 EP claimed
US-20020115888-A1 Novel reagents for heat activated polymer crosslinking NATIONAL STARCH AND CHEMICAL INVESTMENT HOLDING CORPORATION 2002-08-22 US claimed
WO-2002006391-A1 REAGENTS FOR HEAT ACTIVATED POLYMER CROSSLINKING NATIONAL STARCH AND CHEMICAL INVESTMENT HOLDING CORPORATION (US) 2002-01-24 WO claimed
WO-2001094491-A1 RADIATION CURABLE FREE RADICALLY POLYMERIZED STAR-BRANCHED POLYMERS NATIONAL STARCH AND CHEMICAL INVESTMENT HOLDING CORPORATION (US) 2001-12-13 WO claimed
EP-0785221-B1 Adhesives resistant to skin-penetration enhancers NAT STARCH CHEM INVEST (US) 2001-10-10 EP claimed
US-6165563-A Radiation curable free radically polymerized star-branched polymers NATIONAL STARCH AND CHEMICAL INVESTMENT HOLDING CORPORATION (US) 2000-12-26 US claimed
EP-0608891-B1 Radiation Curable Hot Melt Pressure Sensitive Adhesives NAT STARCH CHEM INVEST (US) 1999-09-22 EP claimed
EP-0583417-B1 CROSSLINKED POLED POLYMERS FOR NONLINEAR OPTIC APPLICATIONS AND METHOD OF MAKING THEM DU PONT (US) 1997-01-29 EP claimed
US-5536759-A Radiation cured hot melt pressure sensitive adhesives from photoinitiator-functionalized, crosslinkable copolymers NATIONAL STARCH AND CHEMICAL INVESTMENT HOLDING CORPORATION (US) 1996-07-16 US claimed
US-5416127-A Acrylic copolymers crosslinked with 1-(1-isocyanato 1-methyl ethyl)-3-(1-methylethenyl) benzene NATIONAL STARCH AND CHEMICAL INVESTMENT HOLDING CORPORATION (US) 1995-05-16 US claimed
EP-0608891-A1 Radiation Curable Hot Melt Pressure Sensitive Adhesives National Starch and Chemical Investment Holding Corporation (US) 1994-08-03 EP claimed
EP-0583417-A1 CROSSLINKED POLED POLYMERS FOR NONLINEAR OPTIC APPLICATIONS AND METHOD OF MAKING THEM. DU PONT (US) 1994-02-23 EP claimed
WO-1992019654-A1 CROSSLINKED POLED POLYMERS FOR NONLINEAR OPTIC APPLICATIONS AND METHOD OF MAKING THEM E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-11-12 WO claimed
EP-2978777-B1 ULTRAVIOLET CURABLE PRESSURE SENSITIVE ADHESIVES ASHLAND LICENSING & IP LLC (US) 2019-09-18 EP disclosed
US-8546485-B2 Photocurable dicing die bonding tape HENKEL CORPORATION (US) 2013-10-01 US disclosed
US-20130178585-A1 PHOTOCURABLE DICING DIE BONDING TAPE HENKEL CORPORATION (US) 2013-07-11 US disclosed
WO-1993002384-A1 PREPARATION OF NONLINEAR OPTICAL ELEMENTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-02-04 WO disclosed
WO-1992019654-A1 CROSSLINKED POLED POLYMERS FOR NONLINEAR OPTIC APPLICATIONS AND METHOD OF MAKING THEM E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-11-12 WO disclosed
US-5030696-A Air- or heat-curable protective coatings of unsaturated isocyanate-modified styrene-allyl alcohol copolymer, an acrylic compound and an allyl compound; furniture; toughness MONSANTO COMPANY (US) 1991-07-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020115888-A1 Novel reagents for heat activated polymer crosslinking HSPA4, HSF1, HSPA4L GBA1 4806/4885MIF 1928/4885PTGS1 347/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.