Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | PRKDC | P78527 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31430540 | 0.94 | PDGFRB (0.48) | HTTPOLBCHEK1GAATDP1 | |
| SCHEMBL1013315 | 0.88 | POLB (0.50) | HTTPOLBTDP1CYP3A4L3MBTL1 | |
| SCHEMBL9490047 | 0.87 | PDGFRB (0.52) | POLBGAATDP1L3MBTL1PDGFRB | |
| SCHEMBL12190692 | 0.84 | PDGFRB (0.51) | HTTPOLBCHEK1GAATDP1 | |
| SCHEMBL8902175 | 0.84 | CHEK1 (0.51) | HTTPOLBCHEK1GAATDP1 | |
| SCHEMBL2899450 | 0.84 | POLB (0.52) | HTTPOLBCHEK1GAATDP1 | |
| SCHEMBL9793659 | 0.83 | GAA (0.55) | HTTPOLBCHEK1GAATDP1 | |
| SCHEMBL29160276 | 0.83 | L3MBTL1 (0.47) | HTTPOLBCHEK1GAACYP3A4 | |
| SCHEMBL15823736 | 0.83 | POLB (0.46) | HTTPOLBCHEK1GAATDP1 | |
| SCHEMBL20594284 | 0.83 | PDGFRB (0.59) | GAATDP1NPC1PDGFRBFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113226310-B | 15-PGDH inhibitors | 杏林制药株式会社 | 2024-03-19 | — | — | CN | disclosed |
| CN-113226310-A | 15-PGDH inhibitors | 杏林制药株式会社 | 2021-08-06 | — | — | CN | disclosed |