Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28708249 | 0.94 | POLB (0.46) | POLBHTTTDP1CYP3A4L3MBTL1 | |
| SCHEMBL29734700 | 0.94 | POLB (0.50) | POLBHTTTDP1CYP3A4L3MBTL1 | |
| SCHEMBL5256629 | 0.94 | POLB (0.50) | POLBHTTTDP1CYP3A4L3MBTL1 | |
| SCHEMBL28708248 | 0.92 | POLB (0.50) | POLBHTTCYP3A4L3MBTL1NPC1 | |
| SCHEMBL1953578 | 0.89 | POLB (0.61) | POLBHTTCYP3A4L3MBTL1NPC1 | |
| SCHEMBL28604145 | 0.88 | HTT (0.47) | POLBHTTTDP1CYP3A4L3MBTL1 | |
| SCHEMBL215923 | 0.86 | TPMT (0.51) | POLBHTTCYP3A4L3MBTL1NPC1 | |
| SCHEMBL29465792 | 0.86 | TPMT (0.51) | POLBHTTCYP3A4L3MBTL1NPC1 | |
| SCHEMBL2331208 | 0.85 | ALDH1A1 (0.50) | POLBHTTTDP1CYP3A4NPC1 | |
| SCHEMBL19035895 | 0.85 | TDP1 (0.44) | POLBHTTTDP1CYP3A4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 97 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12605353-B2 | PDIA4 inhibitors and use thereof for inhibiting β-cell pathogenesis and treating diabetes | ACADEMIA SINICA (TW) | 2026-04-21 | — | — | US | disclosed |
| CN-118852118-A | Compounds that inhibit tyrosine kinase activity and pharmaceutical compositions comprising the same | 德州大学系统董事会 | 2024-10-29 | — | — | CN | disclosed |
| US-20240336606-A1 | SUBSTITUTED BENZO OR PYRIDOPYRIMIDINE AMINE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | SHANGHAI ZELGEN PHARMA.TECH CO., LTD. (CN) | 2024-10-10 | — | — | US | disclosed |
| CN-118420595-A | STING agonist ST-76 and synthetic method and application thereof | 河南牧业经济学院 | 2024-08-02 | — | — | CN | disclosed |
| CN-114026083-B | Heterocyclic inhibitors of tyrosine kinases | 德州大学系统董事会 | 2024-07-09 | — | — | CN | disclosed |
| CN-114761025-B | PDIA4 inhibitors and their use for inhibiting beta cell pathologies and for treating diabetes | 施明哲 | 2024-03-12 | — | — | CN | disclosed |
| US-20230373907-A1 | SMALL MOLECULES PROMOTING SYMPATHETIC NERVE REGENERATION | UNIV OREGON HEALTH & SCIENCE (US) | 2023-11-23 | — | — | US | disclosed |
| US-20230373907-A1 | SMALL MOLECULES PROMOTING SYMPATHETIC NERVE REGENERATION | UNIV OREGON HEALTH & SCIENCE (US) | 2023-11-23 | — | — | US | disclosed |
| CN-116444447-B | SOS1 and HDAC double-target quinazoline hydroxamic acid compound as well as preparation method and application thereof | 中国药科大学 | 2023-09-22 | — | — | CN | disclosed |
| EP-4234548-A1 | SUBSTITUTED BENZO OR PYRIDOPYRIMIDINE AMINE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | Suzhou Zelgen Biopharmaceutical Co., Ltd. (CN) | 2023-08-30 | — | — | EP | disclosed |
| CN-101863844-A | Synthesis method of 6, 7-substituent-4-aniline quinazoline | XIANGZHEN BIOLOGY TECHNOLOGY CO LTD | 2010-10-20 | — | — | CN | disclosed |
| EP-2227460-A1 | THERAPEUTIC OXY-PHENYL-ARYL COMPOUNDS AND THEIR USE | Cancer Research Technology Limited (GB) | 2010-09-15 | — | — | EP | disclosed |
| WO-2010076810-A2 | A PROCESS FOR THE PREPARATION OF GEFITINIB | IND-SWIFT LABORATORIES LIMITED (IN) | 2010-07-08 | — | — | WO | disclosed |
| US-20100137586-A1 | Process for the Preparation of Gefitinib | CIPLA LIMITED (IN) | 2010-06-03 | — | — | US | disclosed |
| EP-2155656-A2 | PROCESS FOR THE PREPARATION OF GEFITINIB | Cipla Limited (IN) | 2010-02-24 | — | — | EP | disclosed |
| WO-2009117080-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATON (US) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009053694-A1 | THERAPEUTIC OXY-PHENYL-ARYL COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-04-30 | — | — | WO | disclosed |
| WO-2009053694-A1 | THERAPEUTIC OXY-PHENYL-ARYL COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-04-30 | — | — | WO | disclosed |
| WO-2008125867-A2 | PROCESS FOR THE PREPARATION OF GEFITINIB | CIPLA LIMITED (IN) | 2008-10-23 | — | — | WO | disclosed |
| WO-2008020302-A2 | HETEROAROMATIC QUINOLINE-BASED COMPOUNDS AS PHOSPHODIESTERASE (PDE) INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137586-A1 | Process for the Preparation of Gefitinib | EGFR, BRAF, KRAS | POLB 489/4885HTT 4182/4885TDP1 3471/4885 |
| US-20240336606-A1 | SUBSTITUTED BENZO OR PYRIDOPYRIMIDINE AMINE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | WEE1, SOS1, WEE2 | POLB 2437/4885HTT 4866/4885TDP1 767/4885 |
| US-20230373907-A1 | SMALL MOLECULES PROMOTING SYMPATHETIC NERVE REGENERATION | NGF, GAP43, CHIA | POLB 3992/4885HTT 3119/4885TDP1 2186/4885 |
| US-12605353-B2 | PDIA4 inhibitors and use thereof for inhibiting β-cell pathogenesis and treating diabetes | PDIA4, PDIA5, PDIA6 | POLB 4409/4885HTT 3288/4885TDP1 4219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.