SCHEMBL28604247

SCHEMBL28604247

Cc1ccc(C)n1-c1ccc([N+](=O)[O-])cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 2/20 0.56
ACHE P22303 1/20 0.56
MAPT P10636 6/20 0.54
MEN1 O00255 2/20 0.54
KMT2A Q03164 2/20 0.54
HTT P42858 1/20 0.51
SIRT6 Q8N6T7 2/20 0.50
POLB P06746 4/20 0.49
GSK3A P49840 1/20 0.49
GSK3B P49841 1/20 0.49
ALDH1A1 P00352 6/20 0.47
KDM4E B2RXH2 2/20 0.47
TDP1 Q9NUW8 2/20 0.47
HPGD P15428 1/20 0.47
APEX1 P27695 1/20 0.47
CYP2C19 P33261 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
SCN2A Q99250 1/20 0.46
ADRB1 P08588 1/20 0.46
LMNA P02545 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9187712 0.78 GSK3A (0.56) HSD17B10ACHEMAPTMEN1KMT2A
SCHEMBL7210127 0.78 PTGS2 (0.62) MAPTMEN1KMT2AHTTPOLB
SCHEMBL5698696 0.77 APP (0.52) MAPTMEN1KMT2AHTTALDH1A1
SCHEMBL17172464 0.77 MAPT (0.57) HSD17B10ACHEMAPTMEN1KMT2A
SCHEMBL6988911 0.75 MAPT (0.47) HSD17B10ACHEMAPTMEN1KMT2A
SCHEMBL22567 0.74 ALDH1A1 (0.72) HSD17B10ACHEMEN1KMT2AALDH1A1
SCHEMBL27909482 0.74 ALDH1A1 (0.72) HSD17B10ACHEMEN1KMT2AALDH1A1
SCHEMBL19403708 0.73 HSD17B10 (0.54) HSD17B10ACHEMAPTMEN1KMT2A
SCHEMBL517098 0.73 GSK3A (0.52) HSD17B10ACHEMAPTMEN1KMT2A
SCHEMBL11076830 0.73 LMNA (0.61) MAPTMEN1KMT2AHTTSIRT6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113105381-A Preparation method of biomass-based 2, 5-dimethyl-N-substituted pyrrole derivative 贵州大学 2021-07-13 CN claimed