Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL286257 | 0.84 | PRKAB2 (0.38) | L3MBTL1KDM4ETDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL286258 | 0.84 | PRKAB2 (0.38) | L3MBTL1KDM4ETDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL286008 | 0.82 | ALDH1A1 (0.35) | L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL286010 | 0.82 | ALDH1A1 (0.35) | L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL285784 | 0.82 | TSHR (0.35) | CDC7DBF4L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL286009 | 0.79 | POLB (0.37) | L3MBTL1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL286104 | 0.79 | POLB (0.44) | L3MBTL1CYP2D6CYP2C9CYP2C19TDP1 | |
| SCHEMBL286228 | 0.79 | ALDH1A1 (0.36) | CDC7DBF4L3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL285969 | 0.78 | STAT3 (0.35) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL286049 | 0.76 | GABRA5 (0.43) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427459-A1 | ISOXAZOLE-THIAZOLE DERIVATIVES AS GABA A RECEPTOR INVERSE AGONISTS FOR USE IN THE TREATMENT OF COGNITIVE DISORDERS | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | disclosed |