Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.50 |
| ▸ | XBP1 | P17861 | 1/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29594002 | 1.00 | MAPT (0.50) | MAPTLMNAMAPK1KDM4ECYP1A2 | |
| SCHEMBL28597642 | 0.85 | LMNA (0.38) | MAPTLMNAMAPK1KDM4ECYP1A2 | |
| SCHEMBL28597503 | 0.85 | RAB9A (0.45) | MAPTLMNAMAPK1KDM4ETP53 | |
| SCHEMBL29593441 | 0.85 | MAPT (0.40) | MAPTLMNAMAPK1KDM4ECYP1A2 | |
| SCHEMBL29593143 | 0.85 | RAB9A (0.45) | MAPTLMNAMAPK1KDM4ETP53 | |
| SCHEMBL29593098 | 0.85 | LMNA (0.38) | MAPTLMNAMAPK1KDM4ECYP1A2 | |
| SCHEMBL28597499 | 0.85 | MAPT (0.40) | MAPTLMNAMAPK1KDM4ECYP1A2 | |
| SCHEMBL28609798 | 0.83 | MAPT (0.50) | MAPTLMNAMAPK1KDM4ETP53 | |
| SCHEMBL28597508 | 0.82 | FBP1 (0.43) | MAPTLMNAMAPK1KDM4ETP53 | |
| SCHEMBL29593022 | 0.82 | FBP1 (0.43) | MAPTLMNAMAPK1KDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113185511-B | Pyrimidine compound and preparation method and application thereof | 中国医学科学院医药生物技术研究所 | 2022-04-26 | — | — | CN | disclosed |
| CN-113185511-A | Pyrimidine compound and preparation method and application thereof | 中国医学科学院医药生物技术研究所 | 2021-07-30 | — | — | CN | disclosed |