Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | LMNA | P02545 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | HTT | P42858 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 7/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | GFER | P55789 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | XBP1 | P17861 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28609590 | 0.84 | L3MBTL1 (0.52) | MAPTLMNAKMT2AHTTMAPK1 | |
| SCHEMBL29594002 | 0.83 | MAPT (0.50) | MAPTLMNAKMT2AHTTMAPK1 | |
| SCHEMBL28607232 | 0.83 | MAPT (0.50) | MAPTLMNAKMT2AHTTMAPK1 | |
| SCHEMBL28366757 | 0.80 | DDAH1 (0.59) | MAPTLMNAKMT2AHTTMAPK1 | |
| SCHEMBL28598380 | 0.80 | KDM4E (0.46) | MAPTLMNAKMT2AHTTMAPK1 | |
| SCHEMBL28597642 | 0.80 | LMNA (0.38) | MAPTLMNAKMT2AHTTMAPK1 | |
| SCHEMBL28597503 | 0.80 | RAB9A (0.45) | MAPTLMNAKMT2AMAPK1TDP1 | |
| SCHEMBL28597499 | 0.80 | MAPT (0.40) | MAPTLMNAKMT2AHTTMAPK1 | |
| SCHEMBL29593098 | 0.80 | LMNA (0.38) | MAPTLMNAKMT2AHTTMAPK1 | |
| SCHEMBL29593143 | 0.80 | RAB9A (0.45) | MAPTLMNAKMT2AMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113185511-B | Pyrimidine compound and preparation method and application thereof | 中国医学科学院医药生物技术研究所 | 2022-04-26 | — | — | CN | disclosed |
| CN-113185511-A | Pyrimidine compound and preparation method and application thereof | 中国医学科学院医药生物技术研究所 | 2021-07-30 | — | — | CN | disclosed |