Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21623771 | 0.78 | RAB9A (0.41) | POLBMAPTPKMTSHRLMNA | |
| SCHEMBL10768300 | 0.78 | MEN1 (0.52) | POLBMAPTPKMTSHRLMNA | |
| SCHEMBL2409303 | 0.77 | RAB9A (0.47) | MAPTPKMLMNAKMT2ARAB9A | |
| SCHEMBL9868149 | 0.74 | PTGS2 (0.42) | POLBMAPTPKMTSHRLMNA | |
| SCHEMBL28722535 | 0.73 | PPARG (0.42) | POLBPKMTSHRLMNAKMT2A | |
| SCHEMBL28718970 | 0.72 | POLB (0.47) | POLBMAPTPKMLMNAKMT2A | |
| SCHEMBL28705572 | 0.72 | ALDH1A1 (0.42) | POLBPKMKMT2APPARGRAB9A | |
| SCHEMBL8979785 | 0.72 | RAB9A (0.56) | POLBMAPTPKMLMNAKMT2A | |
| SCHEMBL29464867 | 0.72 | RAB9A (0.56) | POLBMAPTPKMLMNAKMT2A | |
| SCHEMBL22982321 | 0.71 | L3MBTL1 (0.51) | POLBMAPTPKMTSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | disclosed |
| CN-113226464-A | N- (pyridin-2-ylsulfonyl) cyclopropanecarboxamide derivatives and their use in the treatment of CFTR mediated diseases | 诺华股份有限公司 | 2021-08-06 | — | — | CN | disclosed |