Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | GPR142 | Q7Z601 | 2/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3793892 | 0.87 | LTA4H (0.39) | PIK3CACREBBPGPR142RIPK1HPGD | |
| SCHEMBL2113016 | 0.80 | MAPK1 (0.53) | NAMPTGRM5 | |
| SCHEMBL21800527 | 0.79 | RIPK1 (0.62) | RIPK1 | |
| SCHEMBL2111759 | 0.75 | ABHD6 (0.40) | PIK3CAGPR142RIPK1HPGDNAMPT | |
| SCHEMBL17957763 | 0.75 | RIPK1 (0.54) | PIK3CAGPR142RIPK1HPGDKDM4E | |
| SCHEMBL21710240 | 0.75 | MAOA (0.43) | LMNA | |
| SCHEMBL29501124 | 0.75 | RIPK1 (0.54) | PIK3CAGPR142RIPK1HPGDKDM4E | |
| SCHEMBL30895944 | 0.75 | AHR (0.67) | KDM4EALDH1A1GAALMNAGRM5 | |
| SCHEMBL20305088 | 0.74 | PIK3CA (0.39) | PIK3CACREBBPGPR142RIPK1NAMPT | |
| SCHEMBL30314393 | 0.74 | RIPK1 (0.49) | RIPK1HPGDKDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137557-B | Nrf2 modulators | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-09-07 | — | — | CN | disclosed |