Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RCE1 | Q9Y256 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4756836 | 0.72 | NPSR1 (0.45) | NPSR1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL1549089 | 0.70 | ALDH1A1 (0.54) | NPSR1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL28627797 | 0.68 | KDM4E (0.63) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL28623297 | 0.68 | IKBKB (0.47) | NPSR1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL17885172 | 0.68 | KDM4E (0.40) | NPSR1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL20049782 | 0.68 | ALDH1A1 (0.57) | NPSR1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL15872816 | 0.68 | NPSR1 (0.50) | NPSR1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL29790146 | 0.68 | ALDH1A1 (0.46) | NPSR1KDM4EALDH1A1HPGDL3MBTL1 | |
| SCHEMBL25290051 | 0.67 | NPSR1 (0.54) | NPSR1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9296458 | 0.67 | NPSR1 (0.48) | NPSR1KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118108744-A | Isothiazolopyrimidinone compounds, pharmaceutical compositions containing the same and uses thereof | 四川科伦博泰生物医药股份有限公司 | 2024-05-31 | — | — | CN | disclosed |
| CN-113087724-B | Isothiazolopyrimidinone compounds, pharmaceutical compositions containing the same and uses thereof | 四川科伦博泰生物医药股份有限公司 | 2024-01-19 | — | — | CN | disclosed |
| CN-113087724-A | Isothiazolopyrimidinones, pharmaceutical compositions containing the same and uses thereof | 四川科伦博泰生物医药股份有限公司 | 2021-07-09 | — | — | CN | disclosed |