SCHEMBL9296458

SCHEMBL9296458

COC(=O)c1nsnc1Br

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.48
KDM4C Q9H3R0 1/20 0.36
KDM4E B2RXH2 7/20 0.36
STAT3 P40763 1/20 0.36
HIF1A Q16665 1/20 0.36
LMNA P02545 1/20 0.35
MAPT P10636 4/20 0.34
HSD17B10 Q99714 3/20 0.33
KMT2A Q03164 2/20 0.33
TP53 P04637 1/20 0.33
TSHR P16473 1/20 0.33
SMN1; SMN2 Q16637 5/20 0.33
ALDH1A1 P00352 4/20 0.33
HPGD P15428 1/20 0.33
L3MBTL1 Q9Y468 3/20 0.33
PKM P14618 3/20 0.31
MEN1 O00255 1/20 0.31
ELANE P08246 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14582767 0.84 NPSR1 (0.59) NPSR1KDM4CKDM4ESTAT3HIF1A
SCHEMBL23925907 0.75 NPSR1 (0.48) NPSR1KDM4CKDM4ESTAT3HIF1A
SCHEMBL18990911 0.75 NPSR1 (0.48) NPSR1KDM4CKDM4ESTAT3HIF1A
SCHEMBL4115514 0.75 KDM4E (0.49) NPSR1KDM4CKDM4ESTAT3HIF1A
SCHEMBL14891967 0.69 PLAU (0.53) NPSR1KDM4CKDM4EMAPTHSD17B10
SCHEMBL18529020 0.68 NPSR1 (0.50) NPSR1KDM4CKDM4EHSD17B10KMT2A
SCHEMBL2632700 0.68 NPSR1 (0.50) NPSR1KDM4CKDM4EMAPTHSD17B10
SCHEMBL20028494 0.67 SMN1; SMN2 (0.58) KDM4ESTAT3HIF1ALMNAMAPT
SCHEMBL28613328 0.67 NPSR1 (0.43) NPSR1KDM4CKDM4ESTAT3HIF1A
SCHEMBL25290051 0.67 NPSR1 (0.54) NPSR1KDM4CKDM4EMAPTHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260083708-A1 IL-17 MODULATORS AND USES THEREOF NNOCARE PHARMA INC (US) 2026-03-26 US disclosed
EP-4402138-B1 3-PHENOXYAZETIDIN-1-YL-HETEROARYL PYRROLIDINE DERIVATIVES AND THE USE THEREOF AS MEDICAMENT BOEHRINGER INGELHEIM INT (DE) 2025-08-27 EP disclosed
WO-2025119326-A1 NOVEL PRMT5 INHIBITOR AND USE THEREOF 上海湃隆生物科技有限公司 2025-06-12 WO disclosed
US-12297209-B2 Benzodiazepine derivatives as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2025-05-13 US disclosed
US-12268694-B2 Combination pharmaceutical agents as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2025-04-08 US disclosed
US-20240360155-A1 Benzodiazepine Derivatives as RSV Inhibitors ENANTA PHARM INC (US) 2024-10-31 US disclosed
US-20240352037-A1 HETEROAROMATIC MACROCYCLIC ETHER CHEMOTHERAPEUTIC AGENTS NUVALENT, INC. 2024-10-24 US disclosed
WO-2024212941-A1 CBL-B INHIBITOR 北京诺诚健华医药科技有限公司 2024-10-17 WO disclosed
US-12115157-B2 3-phenoxyazetidin-1-yl-heteroaryl pyrrolidine derivatives and the use thereof as medicament BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2024-10-15 US disclosed
US-12054498-B2 Heteroaromatic macrocyclic ether chemotherapeutic agents NUVALENT, INC. (US) 2024-08-06 US disclosed
WO-2019067864-A1 COMBINATION PHARMACEUTICAL AGENTS AS RSV INHIBITORS ENANTA PHARMACEUTICALS, INC. (US) 2019-04-04 WO disclosed
US-20180258102-A1 BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS ENANTA PHARM INC (US) 2018-09-13 US disclosed
EP-3324977-A1 BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS Enanta Pharmaceuticals, Inc. (US) 2018-05-30 EP disclosed
US-9957281-B2 Benzodiazepine derivatives as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2018-05-01 US disclosed
WO-2018064119-A1 CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF BLADE THERAPEUTICS, INC. (US) 2018-04-05 WO disclosed
WO-2018064119-A1 CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF BLADE THERAPEUTICS, INC. (US) 2018-04-05 WO disclosed
WO-2017015449-A1 BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS ENANTA PHARMACEUTICALS, INC. (US) 2017-01-26 WO disclosed
US-20170022221-A1 BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS ENANTA PHARMACEUTICALS, INC. 2017-01-26 US disclosed
US-5326776-A Tetrazoles ABBOTT LABORATORIES (US) 1994-07-05 US disclosed
WO-1993017681-A1 ANGIOTENSIN II RECEPTOR ANTAGONISTS ABBOTT LABORATORIES (US) 1993-09-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240360155-A1 Benzodiazepine Derivatives as RSV Inhibitors GABRA5, GABRA1, GABBR2 NPSR1 114/4885KDM4C 1740/4885KDM4E 1198/4885
US-12115157-B2 3-phenoxyazetidin-1-yl-heteroaryl pyrrolidine derivatives and the use thereof as medicament GPR52, GPR88, GPR68 NPSR1 136/4885KDM4C 3091/4885KDM4E 2658/4885
US-20260083708-A1 IL-17 MODULATORS AND USES THEREOF IL17A, IL2, IL23R NPSR1 662/4885KDM4C 3036/4885KDM4E 3125/4885
US-12297209-B2 Benzodiazepine derivatives as RSV inhibitors GABRA5, GABRA1, GABBR2 NPSR1 114/4885KDM4C 1740/4885KDM4E 1198/4885
US-12268694-B2 Combination pharmaceutical agents as RSV inhibitors ACE, ACE2, SPCS3 NPSR1 2051/4885KDM4C 4501/4885KDM4E 4059/4885
US-20170022221-A1 BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS GABRA5, GABRA1, GABBR2 NPSR1 114/4885KDM4C 1740/4885KDM4E 1198/4885
US-20180258102-A1 BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS GABRA5, GABRA1, GABBR2 NPSR1 114/4885KDM4C 1740/4885KDM4E 1198/4885
US-20240352037-A1 HETEROAROMATIC MACROCYCLIC ETHER CHEMOTHERAPEUTIC AGENTS ABCB1, CYP2C8, PAICS NPSR1 4365/4885KDM4C 1204/4885KDM4E 1505/4885
US-12054498-B2 Heteroaromatic macrocyclic ether chemotherapeutic agents CYP2C8, ABCB1, CYP3A43 NPSR1 4470/4885KDM4C 1272/4885KDM4E 1478/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.