Sugi Predict

Sugi Predict / Compounds / SCHEMBL28613899

SCHEMBL28613899

SCHEMBL28613899

CCOC(=O)c1c(F)c(S(=O)(=O)N[C@@H]2COC[C@H]2CO)cn1C

nearest known ligand 0.35

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.35
▸ LMNA P02545 2/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ KMT2A Q03164 3/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ TP53 P04637 1/20 0.31
▸ TSHR P16473 3/20 0.31
▸ GAA P10253 2/20 0.31
▸ ALOX15 P16050 1/20 0.31
▸ HSD17B10 Q99714 1/20 0.31
▸ CCR8 P51685 1/20 0.30
▸ CYP2C9 P11712 1/20 0.30
▸ PKM P14618 1/20 0.30
▸ ATM Q13315 1/20 0.30
▸ RAB9A P51151 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28613897 1.00 ALDH1A1 (0.35) ALDH1A1LMNASMN1; SMN2KMT2AMEN1
SCHEMBL28618546 0.89 ALDH1A1 (0.36) ALDH1A1LMNASMN1; SMN2KMT2AMEN1
SCHEMBL21670190 0.89 ALDH1A1 (0.36) ALDH1A1LMNASMN1; SMN2KMT2AMEN1
SCHEMBL21699995 0.89 ALDH1A1 (0.36) ALDH1A1LMNASMN1; SMN2KMT2AMEN1
SCHEMBL21670200 0.87 — —
SCHEMBL21699976 0.86 ALDH1A1 (0.37) ALDH1A1LMNASMN1; SMN2KMT2ATP53
SCHEMBL29592764 0.86 ALDH1A1 (0.37) ALDH1A1LMNASMN1; SMN2KMT2ATP53
SCHEMBL21670196 0.86 ALDH1A1 (0.37) ALDH1A1LMNASMN1; SMN2KMT2ATP53
SCHEMBL21700019 0.86 ALDH1A1 (0.37) ALDH1A1LMNASMN1; SMN2KMT2ATP53
SCHEMBL21682570 0.84 LMNA (0.40) ALDH1A1LMNASMN1; SMN2TP53TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3833672-B1 TRICYCLIC INHIBITORS OF HEPATITIS B VIRUS OSPEDALE SAN RAFFAELE SRL (IT) 2024-09-18 — — EP disclosed
CN-113272309-B Tricyclic inhibitors of hepatitis b virus 圣拉斐尔医院有限公司 2024-02-23 — — CN disclosed
US-20230076319-A1 INHIBITORS OF HEPATITIS B VIRUS ANTIOS THERAPEUTICS INC (US) 2023-03-09 — — US disclosed
US-11504382-B2 Tricyclic inhibitors of Hepatitis B virus Antios Therapeutics, Inc. (US) 2022-11-22 — — US disclosed
US-20220110943-A1 TRICYCLIC INHIBITORS OF HEPATITIS B VIRUS OSPEDALE SAN RAFFAELE S.R.L. (IT) 2022-04-14 — — US disclosed
CN-113272309-A Tricyclic inhibitors of hepatitis B virus 圣拉斐尔医院有限公司 2021-08-17 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11504382-B2 Tricyclic inhibitors of Hepatitis B virus HAVCR2, NR1H4, HCCS ALDH1A1 1104/4885LMNA 1438/4885SMN1; SMN2 4878/4885
US-20220110943-A1 TRICYCLIC INHIBITORS OF HEPATITIS B VIRUS HAVCR2, NR1H4, HCCS ALDH1A1 1104/4885LMNA 1438/4885SMN1; SMN2 4878/4885
US-20230076319-A1 INHIBITORS OF HEPATITIS B VIRUS HAVCR2, HDGF, SLC10A1 ALDH1A1 1035/4885LMNA 2132/4885SMN1; SMN2 4876/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.