Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.73 |
| ▸ | PKM | P14618 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 6/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.61 |
| ▸ | ITGA1 | P56199 | 3/20 | 0.54 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.49 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.49 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.49 |
| ▸ | IDH1 | O75874 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28920614 | 0.86 | PKM (0.62) | BRD4PKMMEN1KMT2AHSPD1 | |
| SCHEMBL28607830 | 0.85 | BRD4 (1.00) | BRD4PKMMEN1KMT2APPARG | |
| SCHEMBL28620120 | 0.83 | PKM (0.72) | BRD4PKMMEN1KMT2AHSPD1 | |
| SCHEMBL3086551 | 0.78 | CA12 (0.60) | BRD4PKMMEN1KMT2AMAPT | |
| SCHEMBL28620191 | 0.76 | CA12 (0.58) | BRD4PKMMEN1KMT2AMAPT | |
| SCHEMBL4881258 | 0.76 | PTPN2 (0.55) | BRD4ITGA1PPARGHSPD1PTPN2 | |
| SCHEMBL28607455 | 0.75 | PKM (0.67) | BRD4PKMMEN1KMT2AHSPD1 | |
| SCHEMBL4883514 | 0.73 | FBP1 (0.53) | MEN1KMT2AITGA1PPARGMAPT | |
| SCHEMBL28606739 | 0.73 | BRD4 (0.74) | BRD4PKMMEN1KMT2APPARG | |
| SCHEMBL28607575 | 0.73 | PKM (0.72) | PKMMEN1KMT2AHSPD1PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109824640-B | Coumarin compound and pharmaceutical composition, preparation method and application thereof | 浙江省医学科学院 | 2021-06-29 | — | — | CN | disclosed |