Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29643927 | 1.00 | POLB (0.49) | POLBCYP1A2KMT2ANPC1RAB9A | |
| SCHEMBL29643946 | 0.85 | GRM5 (0.59) | POLBCYP1A2KMT2ANPC1RAB9A | |
| SCHEMBL12090707 | 0.85 | GRM5 (0.59) | POLBCYP1A2KMT2ANPC1RAB9A | |
| SCHEMBL28617499 | 0.84 | GRM4 (0.52) | POLBCYP1A2KMT2ANPC1RAB9A | |
| SCHEMBL31087255 | 0.82 | MEN1 (0.49) | POLBCYP1A2KMT2ANPC1RAB9A | |
| SCHEMBL31087264 | 0.80 | HDAC6 (0.62) | NPC1RAB9AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL28611795 | 0.80 | HDAC6 (0.62) | NPC1RAB9AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL28617023 | 0.78 | RAB9A (0.77) | POLBCYP1A2KMT2ANPC1RAB9A | |
| SCHEMBL15575804 | 0.78 | POLB (0.79) | POLBKMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL31138275 | 0.76 | ALDH1A1 (0.58) | POLBKMT2AALDH1A1MEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113278007-B | Synthetic method of 2-hydroxy-indole-3-ketone compound | 延安大学 | 2022-05-17 | — | — | CN | disclosed |
| CN-113278007-A | Synthetic method of 2-hydroxy-indole-3-ketone compound | 延安大学 | 2021-08-20 | — | — | CN | disclosed |