Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 15/20 | 0.41 |
| ▸ | PCSK9 | Q8NBP7 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22241683 | 0.83 | PCSK9 (0.44) | F10PCSK9KCNH2HCAR3HCAR2 | |
| SCHEMBL22230066 | 0.82 | PCSK9 (0.46) | F10PCSK9KCNH2HCAR3HCAR2 | |
| SCHEMBL22241684 | 0.79 | PCSK9 (0.54) | F10PCSK9KCNH2 | |
| SCHEMBL22406220 | 0.77 | F10 (0.39) | F10PCSK9KCNH2HCAR3HCAR2 | |
| SCHEMBL28635345 | 0.76 | HCAR3 (0.43) | HCAR3HCAR2 | |
| SCHEMBL28622479 | 0.76 | FDPS (0.49) | PCSK9 | |
| SCHEMBL28627403 | 0.75 | PCSK9 (0.56) | PCSK9KCNH2 | |
| SCHEMBL31244877 | 0.75 | PCSK9 (0.70) | PCSK9 | |
| SCHEMBL22230052 | 0.75 | PCSK9 (0.70) | PCSK9 | |
| SCHEMBL28622420 | 0.72 | PCSK9 (0.57) | F10PCSK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113574055-A | PCSK9 inhibitors and methods of use thereof | 阿斯利康(瑞典)有限公司 | 2021-10-29 | — | — | CN | disclosed |
| CN-113412258-A | PCSK9 inhibitors and methods of use thereof | 阿斯利康(瑞典)有限公司 | 2021-09-17 | — | — | CN | disclosed |