Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 10/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 8/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | FDPS | P14324 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28622479 | 0.79 | FDPS (0.49) | RAB9ANPC1PKMSMN1; SMN2GAA | |
| SCHEMBL28627403 | 0.79 | PCSK9 (0.56) | ATM | |
| SCHEMBL22230134 | 0.77 | HCAR3 (0.49) | HCAR3HCAR2RAB9AMAPTTSHR | |
| SCHEMBL28541779 | 0.77 | HCAR3 (0.46) | HCAR3RAB9AMAPTTSHRNPC1 | |
| SCHEMBL22229998 | 0.76 | GPR35 (0.40) | HCAR3HCAR2 | |
| SCHEMBL28631661 | 0.76 | PCSK9 (0.58) | HCAR3HCAR2 | |
| SCHEMBL28617445 | 0.76 | F10 (0.41) | HCAR3HCAR2 | |
| SCHEMBL28622420 | 0.75 | PCSK9 (0.57) | PKMSMN1; SMN2FDPSALDH1A1 | |
| SCHEMBL28539858 | 0.75 | RAB9A (0.45) | HCAR3RAB9AMAPTTSHRNPC1 | |
| SCHEMBL7904169 | 0.74 | SMN1; SMN2 (0.51) | HCAR3HCAR2RAB9AMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113574055-A | PCSK9 inhibitors and methods of use thereof | 阿斯利康(瑞典)有限公司 | 2021-10-29 | — | — | CN | disclosed |
| CN-113412258-A | PCSK9 inhibitors and methods of use thereof | 阿斯利康(瑞典)有限公司 | 2021-09-17 | — | — | CN | disclosed |