Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCSK9 | Q8NBP7 | 3/20 | 0.56 |
| ▸ | GPR55 | Q9Y2T6 | 4/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.44 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.42 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.41 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29775904 | 0.81 | PCSK9 (0.65) | PCSK9GPR55ABCB1ABCC1SYK | |
| SCHEMBL22230065 | 0.81 | PCSK9 (0.62) | PCSK9GPR55ABCB1ABCC1MKNK1 | |
| SCHEMBL28635345 | 0.79 | HCAR3 (0.43) | ATM | |
| SCHEMBL28622479 | 0.78 | FDPS (0.49) | PCSK9CYP2D6 | |
| SCHEMBL22241655 | 0.78 | PCSK9 (0.56) | PCSK9GPR55ABCB1ABCC1WNT3A | |
| SCHEMBL22229998 | 0.78 | GPR35 (0.40) | PCSK9 | |
| SCHEMBL28631661 | 0.78 | PCSK9 (0.58) | PCSK9SYK | |
| SCHEMBL29775946 | 0.78 | PCSK9 (0.56) | PCSK9GPR55ABCB1ABCC1WNT3A | |
| SCHEMBL22406228 | 0.75 | PCSK9 (0.53) | PCSK9GPR55ABCB1ABCC1SYK | |
| SCHEMBL28617445 | 0.75 | F10 (0.41) | PCSK9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113574055-A | PCSK9 inhibitors and methods of use thereof | 阿斯利康(瑞典)有限公司 | 2021-10-29 | — | — | CN | disclosed |
| CN-113412258-A | PCSK9 inhibitors and methods of use thereof | 阿斯利康(瑞典)有限公司 | 2021-09-17 | — | — | CN | disclosed |