Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29405817 | 1.00 | APP (0.45) | APPFLT3RAB9AMAPTKDM4E | |
| SCHEMBL20241344 | 0.88 | NR1H4 (0.47) | APPRAB9AMAPTKDM4EHPGD | |
| SCHEMBL18322205 | 0.88 | NR1H4 (0.47) | APPRAB9AMAPTKDM4EHPGD | |
| SCHEMBL28615795 | 0.85 | THRB (0.50) | APPMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL18322201 | 0.85 | THRB (0.50) | APPMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL18322124 | 0.79 | NPC1 (0.48) | RAB9AALDH1A1HPGDTDP1 | |
| SCHEMBL252040 | 0.76 | LMNA (0.62) | APPFLT3RAB9AMAPTKDM4E | |
| SCHEMBL5403708 | 0.76 | LMNA (0.62) | APPFLT3RAB9AMAPTKDM4E | |
| SCHEMBL18322184 | 0.74 | CACNA1B (0.35) | ALDH1A1 | |
| SCHEMBL28620218 | 0.73 | CYP26A1 (0.43) | MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137557-B | Nrf2 modulators | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-09-07 | — | — | CN | disclosed |