Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | TNKS | O95271 | 10/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 10/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 6/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
| ▸ | TUBB | P07437 | 1/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.42 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.42 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.42 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.42 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.42 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29842180 | 1.00 | PDGFRB (0.49) | PDGFRBTNKSTNKS2PARP2TUBB4A | |
| SCHEMBL28613419 | 0.75 | ADORA3 (0.42) | TNKSTNKS2PARP2TUBB4ATUBB | |
| SCHEMBL29841998 | 0.75 | ADORA3 (0.42) | TNKSTNKS2PARP2TUBB4ATUBB | |
| SCHEMBL4980044 | 0.74 | PDE5A (0.45) | PDGFRBTNKSTNKS2PARP2KMT2A | |
| SCHEMBL28613470 | 0.74 | TUBB4A (0.47) | TNKSTNKS2PARP2TUBB4ATUBB | |
| SCHEMBL29827275 | 0.74 | TUBB4A (0.47) | TNKSTNKS2PARP2TUBB4ATUBB | |
| SCHEMBL4981854 | 0.73 | PDE5A (0.51) | TNKSTNKS2PARP1KMT2A | |
| SCHEMBL29827709 | 0.71 | ALDH1A1 (0.41) | TNKSTNKS2PARP2PARP1GUSB | |
| SCHEMBL4987382 | 0.71 | PDE5A (0.42) | KMT2A | |
| SCHEMBL25921904 | 0.70 | KDM4E (0.46) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113292547-B | 2-aromatic heterocyclic quinazoline ketone compound and preparation method and application thereof | 南方医科大学 | 2022-08-16 | — | — | CN | disclosed |
| CN-113292547-A | 2-aromatic heterocyclic quinazoline ketone compound and preparation method and application thereof | 南方医科大学 | 2021-08-24 | — | — | CN | disclosed |